The dentate gyrus, a major entry point to the hippocampus, gates (or filters) incoming information from the cortex. During sleep or anesthesia, the slow-wave oscillation (SWO) orchestrates hippocampus-neocortex communication, which is important for memory formation. The dentate gate is altered in temporal lobe epilepsy (TLE) early during epileptogenesis, which favors the propagation of patholog...

The SINE WAVE ORCHESTRA (SWO) is a collaborative sound performance project that has been actively performing for the past several years. The basic idea is that each participant plays a sine wave, and by changing its frequency and volume, creates a collection of sine waves as a collective sound representation. Although all SWO works use the same sound representation (i.e., sine waves), different...

The aim of this study was to compare IMRT optimization in the CMS XiO radiotherapy treatment planning system, with and without segment weight optimization. Twenty-one prostate cancer patients were selected for this study. All patients were initially planned with step-and-shoot IMRT (S-IMRT). A new plan was then created for each patient by applying the segment weight optimization tool (SWO-IMRT)...

MOTIVATION Biomedical ontologists to date have concentrated on ontological descriptions of biomedical entities such as gene products and their attributes, phenotypes and so on. Recently, effort has diversified to descriptions of the laboratory investigations by which these entities were produced. However, much biological insight is gained from the analysis of the data produced from these invest...

Squeaky Wheel Optimization (SWO) is a relatively new metaheuristic that has proved to be effective on many real-world problems. At each iteration, SWO does a complete construction of a solution starting from the empty assignment. Although the construction uses information from previous iterations, the complete rebuilding does mean that SWO is generally effective at diversification but can suffe...

The anesthetic propofol elicits many different spectral properties on the EEG, including alpha oscillations (8-12 Hz), Slow Wave Oscillations (SWO, 0.1-1.5 Hz), and dose-dependent phase-amplitude coupling (PAC) between alpha and SWO. Propofol is known to increase GABAA inhibition and decrease H-current strength, but how it generates these rhythms and their interactions is still unknown. To inve...

Post-optimization through local search is known to be a powerful approach for complex optimization problems. In this paper we tackle the problem of optimizing individual activity plans, i.e., plans that concern activities that one person has to accomplish independently of others, taking into account complex constraints and preferences. Recently, this problem has been addressed adequately using ...

Oversubscribed scheduling problems require removing or partially satisfying tasks when enough resources are not available. For a particular oversubscribed problem, Air Force Satellite Control Network scheduling, we find that the best approaches make long leaps in the search space. We find this is in part due to large plateaus in the search space. Algorithms moving only one task at a time are im...

We describe a general approach to optimization which we term "Squeaky Wheel" Optimization (swo). swo, a greedy algorithm is used to construct a solution which is then analyzed to find the trouble spots, i.e., those elements, that, if improved, axe likely to improve the objective function score. That analysis is used to generate new priorities that determine the order in which the greedy algorit...