Introduction: Oculogyric crisis (OGC) is a dystonic reaction characterized as conjugate and typically upward deviation of the eyes lasting from seconds to hours which seen an uncommon neurologic manifestation. Metoclopramide prokinetic agent that frequently prescribed in treatment nausea, vomiting prophylaxis, vomiting. One side effects after metoclopramide acute reactions.Case Presentation: We...

Regulatory agencies in North America and Europe recently re-evaluated the safety of metoclopramide. This re-evaluation resulted in recommendations and restrictions in order to minimise the risk of neurological and other adverse reactions associated with the use of metoclopramide. In the ICU, off-label prescription of metoclopramide is common. We have reviewed the evidence for safety, effectiven...

postoperative nausea and vomiting (ponv) are one of the most common complications of anesthesia and without prophylactic intervention occurs by about one-third of patients under general anesthesia. the aim of this study was to compare the efficacy of ondansetron and metoclopramide in reducing ponv after laparoscopic cholecystectomy. in this study, 60 patients undergoing laparoscopic cholecystec...

BACKGROUND Metoclopramide use is associated with serious and potentially irreversible neurologic side effects. However, it is often used for questionable or unclear indications in clinical practice. OBJECTIVES To (1) determine whether an intervention targeted at the prescribing physician would increase the rate of metoclopramide discontinuation among patients prescribed the medication for que...

One of the agents that cause dystonic reactions is metoclopramide. In this study, we presented three individuals of the same family who were admitted to our hospital while receiving the treatment of metoclopramide because of developing acute dystonic reaction. Appropriate doses of metoclopramide therapy had begun to all brothers with a diagnosis of gastroenteritis. After receiving the first dos...

purpose: to compare the efficacy of granisetron, metoclopramide and dexamethasone in prevention of post operative nausea and vomiting (ponv) after cataract surgery. methods: sixty patients scheduled for cataract surgery with age between 45 to 80 years and with asa class i & ii were enrolled in this clinical trial. the patients were randomly allocated to three 20- person groups. the induction of...

UNLABELLED The effects of metoclopramide on the central nervous system (CNS) in patients suggest substantial brain distribution. Previous data suggest that metoclopramide brain kinetics may nonetheless be controlled by ATP-binding cassette (ABC) transporters expressed at the blood-brain barrier. We used (11)C-metoclopramide PET imaging to elucidate the kinetic impact of transporter function on ...

This study was designed to investigate the role of dopaminergic mechanisms in the control of aldosterone secretion in man. Five normal male subjects in metabolic balance at 150 meq sodium/d and 60 meq potassium/d constant intake received the specific dopamine antagonist, metoclopramide, 10 mg i.v. on 2 consecutive d. On the 1st d, the subjects received an infusion of 5% glucose solution (vehicl...