based on the molecular modeling studies on two major families of anxiolytics and sedative hypnotics (benzodiazepines and barbiturates) a series of phthalimide derivatives were prepared from corresponding di-methyl phthalate derivatives in two steps, namely trans-amidification and ring closer of di-methyl phthalate with urea and base catalysed condensation of 4-bromobenzyl chloride and benzoyl c...

background and objectives cannabinoids which are active compounds of marijuana show some pharmacological effects similar to the opioids. there are also functional interactions between both cannabinoid and opioid systems. in this study we investigated the role of cannabinoid receptors in central amygdala and its interaction with opioid system.   methods in the present study, we investigated the ...

conclusions our results demonstrated that the extract of ob could induce anxiolytic effect in rats after 1 week oral administration. the effect of ob was not induced through changes in motor activity. further investigations are necessary for pharmacological providing of ob and better understanding of its anxiolytic properties and neurobiological mechanisms. results the results showed that after...

putative activity of hydroalcoholic and aqueous infusion extracts of echium amoenum l. was investigated in mice using the rotarod model of motor coordination and the elevated plus maze model of anxiety. the extracts were administered intraperitonealy (i.p.) once, one hour before performing the tests. preliminary phytochemical study of the plant, with standard procedures, showed that it contains...

introduction: sildenafil, a phosphodiesterase-5 (pde5) inhibitor, may have various effects on the central nervous system via the nitric oxide (no)-cyclic guanosine monophosphate (cgmp) pathway. preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. this study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...

based on the extensive application of peganum harmala (p.h) seeds in the asian traditional medicine, we tried to investigate its possible anxiety effect. method: the effect of p.h. extract inhalation was evaluated in adult male rats using elevated plus-maze apparatus. the humidity of prepared ethanol extract was 37%. animals in different groups (n=6) received 2, 4, 6, 12 or 18 gr/ml doses of th...