P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of anticancer drugs. Its broad specificity has been the subject of numerous attempts to inhibit the protein and restore the efficacy of anticancer drugs. The general strategy has been to develop compounds that either c...

Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to explain the sustained hyperexcitability of chronic epilepsy. Here, through methylation analysis of all annotated C-phosphate-G islands and promoter regions in the human genome, we report a pilot study of the methylation profile...

Trichuris dysentery syndrome is caused by Trichuris trichiura which contributes to one of the most common helminthic infections in the world. It is associated with heavy colonic infection that manifests as mucoid diarrhoea, rectal bleeding, rectal prolapse, iron deficiency anaemia, and finger clubbing. Here, we report a case of trichuris dysentery syndrome complicated with severe chronic iron d...

Although the essential role of the adaptor protein SLP-65 in pre-B cell differentiation is established, the molecular mechanism underlying its function is poorly understood. In this study, we uncover a link between SLP-65–dependent signaling and the phosphoinositide-3-OH kinase (PI(3)K)–protein kinase B (PKB)–Foxo pathway. We show that the forkhead box transcription factor Foxo3a promotes light...

Robert Sweet Biophysicist, BNL Biology Department, Upton NY 11973, 631-344-3401, [email protected] Wayne Hendrickson University Professor, Columbia University, New York, NY 10032, 212-305-3456, [email protected] Mark Chance Professor, Case Western Reserve University, Cleveland OH 44106, 216-368-4406, [email protected] Lonny Berman Physicist, National Synchrotron Light Source, Upton ...

Monday December 9: We discussed the sheaf ΩX of regular differential forms on a variety X , which is sheaf of OX-modules, locally free IFF X is smooth, in which case its rank is equal to the dimension. We computed several examples: the sheaf on A is freely generated (on every open set) by dx1, . . . , dxn. On the parabola defined by y = x in A, the elements dx and dy generate on every open set,...

This qualitative study explored general practitioner's and practice nurse's perceptions of barriers and facilitators to the proposed transfer of diabetes care to general practice. Qualitative data were collected through five focus groups. Participants included GPs (n = 55) and practice nurses (n = 11) representing urban (44%), rural (29%) and mixed (27%) practices, in the Irish Mid-West region....

New Prospects for Electrostatic Data Storage Systems Alexander N. Korotkov and Konstantin K. Likharev State University of New York at Stony Brook Stony Brook, NY 11794-3800 [email protected] tel +1-631-632-8159 fax +1-631-632-8774