Here, we evaluated the in vitro anti-HIV-1 activity of the experimental CCR5 inhibitor VCH-286 as a single agent or in combination with various classes of HIV-1 inhibitors. Although VCH-286 used alone had highly inhibitory activity, paired combinations with different drug classes led to synergistic or additive interactions. However, combinations with other CCR5 inhibitors led to effects ranging...

سن گلخوار یونجه، Lygus rugulipennis Poppius (Hemiptera: Miridae)، یکی از آفات مهم یونجه در بسیاری نقاط جهان می‌باشد. زیست‌شناسی آزمایشگاهی و پراسنجه‌های جدول زندگی این آفت پنج دمای 25، 5/27، 30، 5/32 35 درجه سلسیوس، رطوبت نسبی 5 ±60 درصد دوره نوری 16 ساعت روشنایی 8 تاریکی مورد بررسی قرار گرفت. قادر به نشوونما سلسیوس نبود. طولانی‌ترین کوتاه‌ترین طول پورگی به‌ترتیب 5/27 (81/13 روز) (08/8 به‌دست آ...

Diverse morphological tooth deformities are found in various shapes, textures, and prevalence. They can be sporadic or syndromes, nutritional, environmental, genetic, and ethnic related. Most of these tooth-born (ie, patient born with the deformation) deformations (eg, shovel-shaped incisors, tuberculum Carabelli, variations in number and shape of cusps, dens invaginatus, taurodontism) have bee...

A single origin to the diverse mechanisms of metazoan neurogenesis is suggested by the involvement of common signaling components and similar classes of transcription factors. However, in many forms we lack details of where neurons arise, patterns of cell division, and specific differentiation pathway components. The sea urchin larval nervous system is composed of an apical organ, which develop...

experience adverse patient safety events— such as medical injuries or errors—in the course of their care. Those in vulnerable populations, including children under 1 year old are at highest risk for medical injuries related to hospitalization, according to a new study conducted by researchers at the Agency for Healthcare Research and Quality. The study, which uses the recently developed Patient...

sexually active young people should have access to birth control, and only two in 10 object to that proposition.2 Public opinion regarding the scope of sexuality education is consonant with the weight of research in this area. In February 1997, for example, the Consensus Panel on AIDS of the National Institutes of Health declared that the “abstinenceonly” approach “places policy in direct confl...

The terms ∆soil and ∆snow can be ignored when evaluating big catchments on a yearly basis under a Mediterranean climate with dry summers. It is assumed that the soil and snow water storage are almost completely exhausted by the end of the hydrological year. The term ∆aquifers can also be neglected when the global water balance is not greatly affected by subterranean circulation. Equation 1 then...