Metabolic reprogramming is critical for cancer cell proliferation. Glutaminolysis which provides cancer cells with bioenergetics and intermediates for macromolecular synthesis have been intensively studied in recent years. Glutaminase C (GAC) is the first and rate-limiting enzyme in glutaminolysis and plays important roles in cancer initiation and progression. We previously screened a small mol...

Carbamazepine (CBZ) is widely used as an antiepileptic agent and causes rare but severe liver injury in humans. It has been generally recognized that reactive metabolites formed via the metabolic activation reaction contribute to the onset of liver injuries by several drugs. However, the role of CBZ metabolism in the development of liver injury is not fully understood. In this study, we develop...

The causes of prostate cancer are not well understood, but certain risk factors have been identified, namely age, ethnic group, family history, hormone levels and environmental inf luences. The role of androgens in the pathogenesis of prostate cancer remains unclear, but is thought to be pivotal. While androgenic stimulation is needed for prostate development and growth, serum testosterone leve...

The mitochondrial enzyme glutaminase C (GAC) catalyzes the hydrolysis of glutamine to glutamate plus ammonia, a key step in the metabolism of glutamine by cancer cells. Recently, we discovered a class of allosteric inhibitors of GAC that inhibit cancer cell growth without affecting their normal cellular counterparts, with the lead compound being the bromo-benzophenanthridinone 968. Here, we tak...

One hallmark of cancer cells is their adaptation to rely upon an altered metabolic scheme that includes changes in the glycolytic pathway, known as the Warburg effect, and elevated glutamine metabolism. Glutaminase, a mitochondrial enzyme, plays a key role in the metabolism of glutamine in cancer cells, and its inhibition could significantly impact malignant transformation. The small molecule 9...

DOI : 10.5121/vlsic.2010.1401 1 A Simulation Experiment on a Built-In Self Test Equipped with Pseudorandom Test Pattern Generator and Multi-Input Shift Register (MISR) Afaq Ahmad Department of Electrical and Computer Engineering College of Engineering, Sultan Qaboos University P. O. Box 33, Postal Code 123; Muscat, Sultanate of Oman Telephone: (+ 968) 2414 1327 Fax: (+968) 2441 3416 [email protected]...

*Corresponding author: Dr. Manabu Sakakibara: Laboratory of Neurobiological Engineering, Department of Biological Science and Technology, School of High-Technology for Human Welfare, Tokai University, 317 Nishino, Numazu 410-0321, Shizuoka, Japan Tel: +81-55-968-1211 ext. 4504, Fax: +81-55-968-1156, e-mail:[email protected] Articles in PresS. J Neurophysiol (August 11, 2004). 10.1152/jn.00692....