Inhibition of bile acid transport by troglitazone (TGZ) and its major metabolite, TGZ sulfate (TS), may lead to hepatocellular accumulation of toxic bile acids; TS accumulation and hepatotoxicity may be associated with impaired TS biliary excretion. This study evaluated the impact of impaired transport of breast cancer resistance protein (Bcrp) and multidrug resistance–associated protein 2 (Mrp...

http://bmj.com/cgi/content/full/327/7425/1219 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/327/7425/1219/DC1 "List of reviewed articles" References http://bmj.com/cgi/content/full/327/7425/1219#otherarticles 6 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/327/7425/1219#BIBL This arti...

Absorption, distribution, metabolism, and excretion properties of two unformulated model short interfering RNA (siRNAs) were determined using a single internal [H]-radiolabeling procedure, in which the full-length oligonucleotides were radiolabeled by Br/H -exchange. Tissue distribution, excretion, and mass balance of radioactivity were investigated in male CD-1 mice after a single intravenous ...

We sought to determine the neural code(s) for frequency discrimination of vibrotactile stimuli. We tested five possible candidate codes by analyzing the responses of single neurons recorded in primary somatosensory cortex of trained monkeys while they discriminated between two consecutive vibrotactile stimuli. Differences in the frequency of two stimuli could be discriminated using information ...

The repair of injured tendons remains a great challenge, largely owing to a lack of in-depth characterization of tendon cells and their precursors. We show that human and mouse tendons harbor a unique cell population, termed tendon stem/progenitor cells (TSPCs), that has universal stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity. The isolated TSPCs could r...

Tallinna vallutamine aastal 1219 on nii Taanis kui Eestis rahvusliku ajaloonarratiivi oluline sõlmpunkt. Neid sündmusi ümber jutustatud populaarteaduslikes käsitlustes, ajalooromaanides, romantiseeritult kujutatud maalidel, filmides ja joonisfilmides. Kuid kas seda pidasid oluliseks ka Taani kuningas ise tema kaasaegsed? Artikkel analüüsib 1219. aasta vallutust Valdemar II varasemate sõjakäikud...

SYM-1219, a novel oral granule formulation of secnidazole, is under development as single-dose treatment for bacterial vaginosis. This 4-way, randomized, crossover study evaluated the effects of SYM-1219 on electrocardiographic (ECG) parameters in 52 healthy subjects. Subjects were administered single doses of SYM-1219, 2 g (proposed therapeutic dose), 6 g (supratherapeutic dose), placebo, and ...

[This corrects the article on p. 1219 in vol. 7, PMID: 27570530.].

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 204 No. 7 1219–1236 www.jcb.org/cgi/doi/10.1083/jcb.201307057 JCB 1219 Correspondence to James L. Salzer: [email protected] Abbreviations used in this paper: -DG, -dystroglycan; MBP, myelin basic protein; mTor, mammalian target of rapamycin; NDRG1, N-myc downstream– regulated gene-1; P0, myelin protein zero; PI 3-K, phosphatidyli...