NF-κB essential modulator, NEMO, plays a key role in canonical NF-κB signaling induced by a variety of stimuli, including cytokines and genotoxic agents. To dissect the different biochemical and functional roles of NEMO in NF-κB signaling, various mutant forms of NEMO have been previously analyzed. However, transient or stable overexpression of wild-type NEMO can significantly inhibit NF-κB act...

Drosophila nemo was first identified as a gene required for tissue polarity during ommatidial development. We have extended the analysis of nemo and found that it participates in multiple developmental processes. It is required during wing development for wing shape and vein patterning. We observe genetic interactions between nemo and mutations in the Notch, Wingless, Frizzled and Decapentapleg...

NEtwork MObility Basic Support (NEMO BS) protocol has been investigated to provide Internet connectivity of a group of nodes, which is suitable for Intelligent Transportation Systems (ITS) applications. Since NEMO BS is based on Mobile IPv6 (MIPv6), it often increases traffic load and handover latency due to the handover procedure. Thus, schemes combining Proxy MIPv6 (PMIPv6) with NEMO (PNEMO) ...

In recent years, extensive studies have been undertaken in order to provide Quality of Service (QoS) for individual mobile nodes in wireless networks. With the development of Network Mobility (NEMO) technology, the provision of QoS for moving networks based on NEMO is emerging as a new research area. However, it is very difficult to directly apply existing QoS technologies to NEMO because of th...

Background: Until now, the comparison of the rK39 strip test (RKT) and direct ag-glutination test (DAT) for detection of visceral leishmaniasis (VL) is exclusively based on either positive or negative qualification of the reaction outcome. Objective: In this study, we compared the diagnostic performance of RKT and DAT for VL both qualitatively and semi-quantitatively. Methods: For comparison ba...

Nuclear factor kappaB (NF-kappaB) is one of the main transcription factors involved in regulating apoptosis, inflammation, chronic liver disease, and cancer progression. The IKK complex mediates NF-kappaB activation and deletion of its regulatory subunit NEMO in hepatocytes (NEMO(Delta hepa)) triggers chronic inflammation and spontaneous hepatocellular carcinoma development. We show that NEMO(D...

Nuclear factor-κB essential modulator (NEMO), the regulatory subunit of the IκB kinase complex, is a critical component of the NF-κB pathway. Hypomorphic mutations in the X-linked human NEMO gene cause various forms of anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID). All known X-linked EDA-ID-causing mutations impair NEMO protein expression, folding, or both. We describe here 2 E...

Genetic mouse studies suggest that the NFB pathway regulator NEMO (also known as IKK ) controls chronic inflammation and carcinogenesis in the liver. However the molecular mechanisms explaining the function of NEMO are not well defined. Here we report that overexpression of the cell cycle regulator p21 is a critical feature of liver inflammation and carcinogenesis caused by the loss of NEMO. NE...