The prevalence of furazolidone, nitrofurantoin, and metronidazole resistance among Helicobacter pylori strains was assessed with 431 clinical isolates. Fifty-two percent were metronidazole resistant, compared to 2% (7 of 431) with resistance to furazolidone and nitrofurantoin. All seven furazolidone- and nitrofurantoin-resistant isolates were also metronidazole resistant. rdxA, frxA, and fdxB k...

Furazolidone, on complexing with DNA, led to its thermal stabilization. The increase in transition temperature of DNA (delta Tm) increased linearly with % A--T content. Increasing concentration of Cu(II) ions progressively lowered the transition temperature of DNA, but Cu(II) ions were not equally effective in lowering the transition temperature of furazolidone-DNA complex. When equimolar amoun...

Several aspects of Helicobacter pylori eradication have been meta-analyzed; however, nitrofuran-based therapies constitute an exception. The aim of this study was the systematic review and meta-analysis of the effect of furazolidone- and nitrofurantoin-based regimens in the eradication of infection. Studies evaluating the effects of nitrofurans on H. pylori were identified from Medline, EMBASE,...

Ninety-four U.S. students who acquired diarrhea in Mexico were treated with furazolidone (47 subjects) or ampicillin (47 subjects) on a double-blind random basis. Of 47 students, 26 (55%) who received furazolidone (100 mg four times daily for 5 days) recovered from illness within 48 h after initiation of therapy, in contrast to 15 of 47 (32%) who received ampicillin (500 mg four times daily for...

Treatment of typhoid fever with furazolidone produces a high cure rate. This is a clinical curiosity, as furazolidone is described to be poorly absorbed. The present study examined whether furazolidone could produce unequivocal clinical response and, if so whether this was due to the drug producing bactericidal levels in the serum. Twenty one patients selected by defined criteria were treated w...

Dietary furazolidone (500 ppm or higher) significantly slowed the growth of chicks fed either a conventional or a purified diet and of turkeys fed a conventional diet. Deaths were significantly increased in turkeys fed 500 ppm and in chicks fed 700 ppm in the purified diet. Ratio of heart to body weight was significantly increased by furazolidone in turkeys, but not in chicks. Furazolidone did ...

The so-called " serotonin syndrome " (SS) is a potentially serious condition of central and peripheral serotonergic hyperstimulation. It is caused by the administration of single drugs or combinations of drugs that elevate synaptic levels of serotonin. It can arise following both therapeutic doses and overdoses, while the most serious cases are usually caused by an unintended synergism between ...

The occurrence of strains resistant to metronidazole is causing failure of the 4-drug regimen for eradication of Helicobacter pylori in the Islamic Republic of Iran. This study compared the in vitro efficacy of furazolidone with metronidazole, clarithromycin, amoxicillin and tetracycline in 70 H. pylori isolates from dyspeptic patients. Of the isolates, 33% were resistant to metronidazole but a...

BACKGROUND Helicobacter pylori infection is a common chronic human bacterial infection. Triple- therapy regimen containing a proton pump inhibitor, clarithromycin, and either amoxicillin or metronidazole is commonly used as first-line treatment for its eradication. However, it may not provide the acceptable eradication rate. The present study was designed to evaluated efficacy of low dose furaz...