BACKGROUND AND PURPOSE In the National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study, major neurological improvement within 24 hours (MNI) occurred significantly more frequently with recombinant tissue plasminogen activator (rtPA) treatment than with placebo. We explored the relationship between MNI and 3-month favorable outcome and sought clinical predictors of MNI....

MNI coordinates determined using SPM2 and FSL/FLIRT with the ICBM-152 template were compared to Talairach coordinates determined using a landmark-based Talairach registration method (TAL). Analysis revealed a clear-cut bias in reference frames (origin, orientation) and scaling (brain size). Accordingly, ICBM-152 fitted brains were consistently larger, oriented more nose down, and translated sli...

BACKGROUND Since its inception in 1934 by the legendary Dr. Wilder Penfield, the Montreal Neurological Institute (MNI) has provided world-renowned instruction in neurosurgery and related neurosciences, training many of the most prominent figures in the history of neurosurgery. Less well known is the role of the MNI in training the first African-American board-certified neurosurgeons. METHODS ...

Many functional imaging studies match their data to a brain template from the Monteal Neurological Institute (MNI). It is common for such studies to report activation coordinates and estimated Brodmann areas (BAs) in terms of the 1988 atlas of Talairach and Tournoux. This can be problematic, as the brains in the Talairach atlas and MNI template differ significantly in shape and size. This poste...

A novel stable donor/acceptor-supported MnI-metallasilanone 3 was synthesized. The intramolecular silanone-MnI interaction induces a highly strained three-membered cyclic structure, leading to an exceptionally high reactivity of as donor/acceptor complex silanone. Indeed, metallasilanone readily reacts with various small molecules such H2 or ethylene gas in mild conditions.

This essay traces the simultaneous development of two distinct efforts to unify brain sciences in twentieth century—one originating at Montreal Neurological Institute (MNI) and other Massachusetts Technology (MIT). Both coalesced around investigations memory but displayed profoundly different disciplinary styles. At MNI, loss surgical patients crystallized a form research that eventually became...