نتایج جستجو برای: فرایند tcap
تعداد نتایج: 36142 فیلتر نتایج به سال:
PURPOSE To evaluate erectile function (EF) and voiding function following primary targeted cryoablation of the prostate (TCAP) for clinically localized prostate cancer (CaP) in a contemporary cohort. MATERIALS AND METHODS We retrospectively reviewed all patients treated between 2/2000-5/2006 with primary TCAP. Variables included age, Gleason sum, pre-TCAP prostate specific antigen (PSA), pros...
Tcap/telethonin encodes a Z-disc protein that plays important roles in sarcomere assembly, sarcomere-membrane interaction and stretch sensing. It remains unclear why mutations in Tcap lead to limb-girdle muscular dystrophy 2G (LGMD2G) in human patients. Here, we cloned tcap in zebrafish and conducted genetic studies. We show that tcap is functionally conserved, as the Tcap protein appears in th...
The existence of the teneurin C-terminal associated peptides (TCAP) was reported in 2004 after screening a rainbow trout hypothalamic cDNA for corticotropin-releasing factor (CRF)-related homologs. In vertebrates, there are four TCAP paralogs, where each peptide is associated with a teneurin transmembrane protein. The TCAPs are 40 or 41 amino acids in length and possess less than 20% residue id...
OBJECTIVES We sought to explore the relationship between a Tcap gene (TCAP) abnormality and cardiomyopathy. BACKGROUND Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) cause severe heart failure and sudden death. Recent genetic investigations have revealed that mutations of genes encoding Z-disc components, including titin and muscle LIM protein (MLP), are the primary cause ...
Circadian rhythms are important for healthy cardiovascular physiology and are regulated at the molecular level by a circadian clock mechanism. We and others previously demonstrated that 9-13% of the cardiac transcriptome is rhythmic over 24 h daily cycles; the heart is genetically a different organ day versus night. However, which rhythmic mRNAs are regulated by the circadian mechanism is not k...
BACKGROUND AND PURPOSE The stress-related neuropeptide, corticotropin-releasing factor (CRF), has become an important focus of studies of cocaine addiction, and in particular, the effects of stress on cocaine-related behaviours. A recently discovered peptide system, the teneurin C-terminal associated peptides (TCAP), has been implicated in the regulation of the stress response, via a CRF-relate...
Tubular channel angular pressing (TCAP) process was proposed recently as a novel severe plastic deformation technique for producing ultrafine grain and nanostructured tubular components. In this paper, an upper-bound approach was used to analyze the TCAP process. Deformation of the material during TCAP process is analyzed using upper-bound analysis to determine maximum required load. The effect...
Tubular channel angular pressing (TCAP) is a new and novel severe plastic deformation (SPD) technique suitable for fabrication of bulk nanograined tubular materials. There are several parameters in TCAP process. The present paper investigates the effects of curvature angles, deformation ratio (= maximum radius during TCAP/ initial radius) and deformation direction on the plastic deformation beh...
Mood disorders, including anxiety and depression, are thought to be characterized by disrupted neuronal synapses and altered brain plasticity. The etiology is complex, involving numerous regions of the brain, comprising a multitude of neurotransmitter and neuromodulator systems. Recently, new studies on the teneurins, an evolutionary ancient family of type II transmembrane proteins have been sh...
Teneurin C-terminal associated peptides (TCAP), bioactive located on the end of teneurin proteins, have been shown to regulate stress axis functions due high conservation between TCAP and corticotropin releasing factor (CRF). Additionally, recent work demonstrated that can increase metabolism in rats via glucose metabolism. These metabolic actions are not well described other organisms, includi...
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