Caenorhabditis elegans contains two muscle regulatory myosin light chain genes, mlc-1 and mlc-2. To determine their in vivo roles, we identified deletions that eliminate each gene individually and both genes in combination. Functions of mlc-1 are redundant to those of mlc-2 in both body-wall and pharyngeal muscle. mlc-1(0) mutants are wild type, but mlc-1(0) mlc-2(0) double mutants arrest as in...

MLC++, the Machine Learning library in C++ is a set of libraries and utilities that can aid developers in interfacing machine learning technology, aid users in selecting an appropriate algorithm for a given task, and aid researchers in developing new algorithms, especially hybrid algorithms and multi-strategy algorithms. D2.1.2.1 Motivation for MLC++ A learning algorithm cannot outperform any o...

Multileaf collimator (MLC) technology has been newly introduced with the Cyberknife system. This study investigated the advantages of this system compared with the conventional circular collimator (CC) system. Dosimetric comparisons of MLC and CC plans were carried out. First, to investigate suitable target sizes for the MLC mode, MLC and CC plans were generated using computed tomography (CT) i...

Introduction: Nowadays tendency to apply more degrees of freedom in high-tech radiotherapy systems, and consequent complex process to optimize dose calculation and delivery algorithms, is a challenge of radiation therapy optimization. Faster MLC speed, dose rate, Gantry angle variation, and other degrees, which have been utilized in IMRT, IMAT, VMAT, improved modulation of inte...

background: surgical technique using small-diameter  instruments and single-incision laparoscopy are two new options for less invasive laparoscopic cholecystectomy (lc). in this study, we have compared mini-lc (mlc) with single-incision lc (silc). materials and methods: this study is a randomized clinical trial conducted on the patients diagnosed with  symptomatic cholelithiasis who underwent l...

Myosin light chain genes of human hematopoietic cells have not been fully characterized. We previously reported the cloning of the full-length cDNAs of 20 kDa regulatory myosin light chain (MLC-2), named as MLC-2A, from Meg-01, a human megakaryoblastic leukemia cell line (J. Smooth Muscle Res. 37: 25-38, 2001). We now cloned another MLC-2 isoforms from human platelets and U937, a human monocyti...

Background: Recently, multileaf collimators (MLC) have become an important part of any LINAC collimation system because they reduce the treatment planning time and improve the conformity. Important factors that affect MLCs collimation performance are leaves material composition and their thickness.Objective: In this study, we investigate main dosimetric parameters of a typical MLC includi...

The AccuLeaf mMLC featuring four multileaf-collimator (MLC) banks has been used for the first time for an experimental comparison of conventional two-bank with novel four-bank dynamic MLC tracking of a two-dimensional sinusoidal respiratory motion. This comparison was performed for a square aperture, and for three conformal treatment apertures from clinical radiotherapy lung cancer patients. Th...

PURPOSE Advanced radiotherapy delivery systems designed for high-dose, high-precision treatments often come equipped with high-definition multi-leaf collimators (HD-MLC) aimed at more finely shaping radiation dose to the target. In this work, we study the effect of a high definition MLC on spine stereotactic body radiation therapy (SBRT) treatment plan quality and plan deliverability. METHODS...