BACKGROUND In vivo evaluation of cholinergic circuits of the human brain has recently been introduced using a transcranial magnetic stimulation (TMS) protocol based on coupling peripheral nerve stimulation with motor cortex TMS (short latency afferent inhibition, SAI). SAI is reduced in Alzheimer's disease (AD) and drugs enhancing cholinergic transmission increase SAI. METHODS We evaluated wh...

Peripheral nerve stimulation inhibits the motor cortex, and the process has been termed short-latency afferent inhibition (SAI) at interstimulus intervals (ISIs) of ∼20 ms. The objective of the present study was to test how SAI interacts with short-interval intracortical inhibition (SICI) under different stimulation conditions. We studied 20 healthy volunteers. Surface electromyogram was record...

When somatosensory input via electrical stimulation of a peripheral nerve precedes a transcranial magnetic stimulation (TMS) pulse over the primary motor cortex (M1) the corticospinal output is substantially reduced, a phenomenon known as short-latency afferent inhibition (SAI). The present study investigated SAI during rest and during pre-movement, phasic and tonic components of movement. Part...

T. Sai Vignesh,Premaditya Chhetri, K. Vijay Sai, S. Deepa, Dwarakarani Rao, R. Gowrishankar, S. Kailas and K. Venkataramaniah * Department of Physics, Sri Sathya Sai Institute of Higher Learning, Prasanthinilayam 515134 2 Department of Physics, Sri Sathya Sai Institute of Higher Learning, Anantapur 515001 3 Nuclear Physics Division, Bhabha Atomic Research Centre, Mumbai 400085 * email:vrkamiset...

Older adults' memory reports are often less complete and accurate than those by younger adults. The current study assessed the suitability of the Self-Administered Interview (SAI) as retrieval support for older eyewitnesses, and examines whether experience with the SAI leads to improved performance on subsequent events where the SAI is not used. Participants recalled an event with the SAI or fr...

24 Peripheral nerve stimulation inhibits the motor cortex and the process has been termed 25 short latency afferent inhibition (SAI) at interstimulus intervals (ISI) of ~20 ms. The 26 objective of the present study is to test how SAI interacts with short interval intracortical 27 inhibition (SICI) under different stimulation conditions. We studied 20 healthy 28 volunteers. Surface electromyogra...

Short-latency afferent inhibition (SAI) occurs when a single transcranial magnetic stimulation (TMS) pulse delivered over the primary motor cortex is preceded by peripheral electrical nerve stimulation at a short inter-stimulus interval (∼ 20-28 ms). SAI has been extensively examined at rest, but few studies have examined how this circuit functions in the context of performing a motor task and ...

The Spiritual Assessment Inventory (SAI) is a relationally-based measure designed to assess two dimensions of spiritual development: Awareness of God and Quality of Relationship with God. The present article reports the results of two studies: exploratory and confirmatory factor analyses of a revised SAI, which replicated five factors, and a factor analysis of a revised SAI with a new Impressio...

BACKGROUND To examine whether the social adaptability index (SAI) alone or components of the index provide a better explanatory model for self-care and diabetes outcomes. METHODS Six hundred fifteen patients were recruited from two primary care settings. A series of multiple linear regression models were run to assess (1) associations between the SAI and diabetes self-care/outcomes, and (2) a...