The nexin-dynein regulatory complex (N-DRC) forms a cross-bridge between the outer doublet microtubules of the axoneme and regulates dynein motor activity in cilia/flagella. Although the molecular composition and the three-dimensional structure of N-DRC have been studied using mutant strains lacking N-DRC subunits, more accurate approaches are necessary to characterize the structure and functio...

BACKGROUND Exposure to UV radiation is associated with cutaneous malignant melanoma (CMM). In mammalian cells, UV radiation induces DNA damage that can be repaired by the nucleotide excision repair system. We designed this case-control study to determine whether DNA repair capacity (DRC) is associated with the risk of CMM and to identify risk factors that may interact biologically with DRC in t...

Suboptimal cellular DNA repair capacity (DRC) has been shown to be associated with enhanced cancer risk, but genetic variants affecting the DRC phenotype have not been comprehensively investigated. In this study, with the available DRC phenotype data, we analyzed correlations between the DRC phenotype and genotypes detected by the Illumina 317K platform in 1,774 individuals of European ancestry...

Crossbred yearling steers ( = 360; 395 ± 33.1 kg initial BW) were used to evaluate the effects of dry-rolled corn (DRC) particle size in diets containing 20% wet distiller's grains plus solubles on feedlot performance, carcass characteristics, and starch digestibility. Steers were used in a randomized complete block design and allocated to 36 pens (9 pens/treatment, with 10 animals/pen). Treatm...

We developed quantitative assays to test the hypothesis that the N-DRC is required for integrity of the ciliary axoneme. We examined reactivated motility of demembranated drc cells, commonly termed "reactivated cell models." ATP-induced reactivation of wild-type cells resulted in the forward swimming of ∼90% of cell models. ATP-induced reactivation failed in a subset of drc cell models, despite...

Glaucoma affected the ability to detect low-contrast, flickering patterns ('DRC' measurement). DRC patterns were foveally viewed, of low spatial frequency, and flickering at 8 hertz. Interocular comparisons were performed in control subjects, in ocular hypertensives, and in glaucoma patients with asymmetric damage. Interocular differences in DRC tended to be of greater magnitude in the glaucoma...