Antimicrobial epsilon-poly-L-lysine (ePL) is secreted by Streptomycetaceae bacteria, and the mechanism of ePL biosynthesis remains to be elucidated. We previously reported that an unknown ePL derivative accumulates in the culture medium of ePL-producing bacteria when glycerol is added to the culture medium (Nishikawa and Ogawa, Appl. Environ. Microbiol. 68:3575-3581, 2002). In this study, by us...

ɛ-Polylysine (EPL) is used as a natural preservative in food. However, few studies have been conducted to assess the beneficial functions of dietary EPL. The purpose of this study was to elucidate the mechanism underlying the inhibition of neutral and acidic sterol absorption and hepatic enzyme activity-related fatty acid biosynthesis following EPL intake. EPL digest prepared using an in vitro ...

Current literature suggests that tendonitis of the extensor pollicis longus (EPL) is a rare condition that has a high rate of progression to rupture. This study documents the prodrome of impending EPL rupture in patients with prior nondisplaced distal radial fracture. A retrospective study identified patients with EPL tendonitis or tendon rupture. Seven patients (6 females and 1 male) had susta...

In this study, we show that beam model differences play an important role in the comparison of does calculated with various algorithms for lung cancer treatment planning. These differences may impact the accurate correlation of dose with clinical outcome. To accomplish this, we modified the beam model penumbral parameters in an equivalent path length (EPL) algorithm and subsequently compared th...

in English What is the impact of employment protection legislation (EPL) on employment and productivity? Ambiguous seems to be the most robust finding. In this paper we explore this ambiguity further. We consider a setup in which the impact of various types of EPL on both employment and productivity is potentially ambiguous, we construct a vintage model with specific investments by firms and wo...

PURPOSE Early pregnancy loss (EPL) affects 50-70% pregnant women in first trimester. The precise molecular mechanisms underlying EPL are far from being fully understood. Therefore, we aim to identify the molecular signaling pathways relating to EPL. EXPERIMENTAL DESIGN We performed proteomics and bioinformatics analysis of the placental villi in women who have undergone EPL and in normal preg...

OBJECTIVES To investigate the effects of adding the selective aldosterone receptor antagonist eplerenone to ACE inhibition on endothelium-dependent vasodilation in rats with chronic heart failure (CHF). BACKGROUND Addition of the non-selective aldosterone antagonist spironolactone to ACE-inhibitors reduces mortality and morbidity in CHF and improves endothelial vasomotor dysfunction, but is a...