( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 125 days. 2005/0171757 A1 * 8/2005 Appleby ........................... 704/2 2006/0116867 A1 * 6/2006 Moore .............................. 704/2 2006/0287847 A1 * 12/2006 Moore .............................. 704/8 2007/0010989 A1 * 1/2007 Faruquieetal..................... 704/2 200...

The primary aim was to study the relationship between individual serum levels of 25-hydroxyvitamin D and 4b-hydroxycholesterol, which is an endogenous biomarker of the drug-metabolizing CYP3A enzymes. In addition, the relationship between this biomarker and inflammation, measured as C-reactive protein (CRP), was investigated. Serum samples were used from a recently performed clinical trial in p...

The primary aim was to study the relationship between individual serum levels of 25-hydroxyvitamin D and 4b-hydroxycholesterol, which is an endogenous biomarker of the drug-metabolizing CYP3A enzymes. In addition, the relationship between this biomarker and inflammation, measured as C-reactive protein (CRP), was investigated. Serum samples were used from a recently performed clinical trial in p...

Joseph Kwan1†, Damian Jenkinson2, Mike Vassallo3, Nicola Englyst4 & V Hugh Perry5 †Author for correspondence 1Royal Bournemouth Hospital, Department of Medicine for the Elderly, Castle Lane East, Bournemouth, BH7 7DW, UK Tel.: +44 1202 704 590; Fax: +44 1202 704 542; E-mail: [email protected] 2Tel.: +44 1202 705 292; Fax: +44 1202 704 542; E-mail: damian.jenkinson@ rbch.nhs.uk 3Tel.: +44 ...

1.1. Normed spaces. Recall that a (real) vector space V is called a normed space if there exists a function ‖ · ‖ : V → R such that (1) ‖f‖ ≥ 0 for all f ∈ V and ‖f‖ = 0 if and only if f = 0. (2) ‖af‖ = |a| ‖f‖ for all f ∈ V and all scalars a. (3) (Triangle inequality) ‖f + g‖ ≤ ‖f ||+ ‖g‖ for all f, g ∈ V . If V is a normed space, then d(f, g) = ‖f−g‖ defines a metric on V . Convergence w.r.t ...

INTRODUCTION ................................................................ Cellular Responses to Amino Acid Restriction.................................. Key Position ofAminoacyl sRNA Synthetases................................... MUTANTS WITH MODIFiED AMiNOACYL sRNA SYNTHETASES....................... Conditionally Expressed Mutations........................................... General backgr...