Eun Mi Lee1,y, Seung Sik Lee1,y, Bhumi Nath Tripathi, Hyun Suk Jung, Guang Ping Cao, Yuno Lee, Sudhir Singh, Sung Hyun Hong, Keun Woo Lee, Sang Yeol Lee, Jae-Young Cho and Byung Yeoup Chung* Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 29 Geumgu-gil, Jeongeup 580-185, Republic of Korea, Department of Biochemistry, College of Natural Sciences, Kangwon National...

A mechanism is defined for use by message servers in transferring data between hosts. The mechanism, called the MSDTP, is defined in terms of a model of the process as a translation between two sets of items, the abstract entities such as 'strings' and 'integers', and the formats used to represent such data as a byte stream. A proposed organization of a general data transfer mechanism is descri...

The long-acting opioid methadone displays considerable unexplained interindividual pharmacokinetic variability. Methadone metabolism clinically occurs primarily by N-demethylation to 2-ethyl-1,5-dimethyl3,3-diphenylpyrrolidine (EDDP), catalyzed predominantly by CYP2B6. Retrospective studies suggest that the common allele variant CYP2B6*6 may influence methadone plasma concentrations. The cataly...

Guanfu base A (GFA) is a novel heterocyclic antiarrhythmic drug isolated from Aconitum coreanum (Lèvl.) rapaics and is currently in a phase IV clinical trial in China. However, no study has investigated the influence of GFA on cytochrome P450 (P450) drug metabolism. We characterized the potency and specificity of GFA CYP2D inhibition based on dextromethorphan O-demethylation, a CYP2D6 probe sub...

Effective population size is fundamental in population genetics and characterizes genetic diversity. To infer past population dynamics from molecular sequence data, coalescent-based models have been developed for Bayesian nonparametric estimation of effective population size over time. Among the most successful is a Gaussian Markov random field (GMRF) model for a single gene locus. Here, we pre...

Intracerebral hemorrhage (ICH) is a fatal stroke subtype with significant public health impact. Although neuroinflammation is a leading cause of neurological deficits after ICH, no imaging tool is currently available to monitor brain inflammation in ICH patients. Given the role of TSPO in neuroinflammation, herein we investigate whether a second-generation TSPO ligand, [125 I]IodoDPA-713 can be...

1 To whom correspondence should be addressed: Sudhir Paul, Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas–Houston Medical School, 6431 Fannin, Houston, Texas 77030, USA, Tel.: 713-500-5347; Fax: 713-500-0574; E-mail: [email protected]; Or Eric L. Brown, Center for Infectious Diseases, University of Texas School of Public Health, 1...

Reciprocal cleft and pistillate floral bud grafts were made between parthenocarpic ;Fertilla' and nonparthenocarpic ;MSU 713-5' cucumber (Cucumis sativus L.) lines to localize the site for stimulation of parthenocarpic fruit set. No fruit set on ;MSU 713-5' controls, scion grafted to ;Fertilla,' or rootstock with ;Fertilla' as the scion. ;Fertilla' controls, rootstock, and scions all produced p...

Stanislaw R. Burzynski Burzynski Clinic, Houston U.S.A. __________________________________________________________________________________ *Correspondence: Stanislaw R. Burzynski, Burzynski Clinic, Houston USA; Tel: (713) 335-5697; Fax: (713) 335-5658; e-mail: [email protected]