نتایج جستجو برای: سندرم میلودیسپلاستیک (MDS-RAEB)
تعداد نتایج: 12485 فیلتر نتایج به سال:
مقدمه و هدف :سندرم میلودیسپلاستیک (mds)، ناهنجاری هماتوپویتیک است که به وسیله تغییرات دیسپلاستیک سلول های پیش ساز خونی مشخص و منجر به خونسازی غیر موثر در مغز استخوان و سیتوپنی در خون محیطی می شود. امروزه در دامپزشکی تشخیص و طبقه بندی نئوپلاسم های خون در سگ و گربه بر اساس طبق بندی fab توسعه یافته است. ناهنجاری خونی مربوط به دیسپلازی سلول های خون مجموعا به عنوان سندرم میلودیسپلاستیک در سیستم fab ...
مقدمه و هدف :سندرم میلودیسپلاستیک (MDS)، ناهنجاری هماتوپویتیک است که به وسیله تغییرات دیسپلاستیک سلول های پیش ساز خونی مشخص و منجر به خونسازی غیر موثر در مغز استخوان و سیتوپنی در خون محیطی می شود. امروزه در دامپزشکی تشخیص و طبقه بندی نئوپلاسم های خون در سگ و گربه بر اساس طبق بندی FAB توسعه یافته است. ناهنجاری خونی مربوط به دیسپلازی سلول های خون مجموعا به عنوان سندرم میلودیسپلاستیک در سیس...
INTRODUCTION The bone marrow (BM) microenvironment plays an important role in the pathogenesis of myelodysplastic syndromes (MDS) through a reciprocal interaction with resident BM hematopoietic cells. We investigated the differences between BM mesenchymal stromal cells (MSCs) in MDS and normal individuals and identified genes involved in such differences. MATERIALS AND METHODS BM-derived MSCs...
The International Prognostic Scoring System (IPSS) has been widely used to predict the prognosis of patients with myelodysplastic syndrome (MDS). However, IPSS does not always provide a sufficiently precise evaluation of patients to allow the appropriate choice of clinical interventions. Here, we analyzed the expression of Bmi-1, which is required to regulate the self-renewal in CD34+ cells fro...
BACKGROUND The MDS-IWG and NCCN currently endorse both FAB and WHO classifications of MDS and AML, thus allowing patients with 20-30 % bone marrow blasts (AML20-30, formerly MDS-RAEB-t) to be categorised and treated as either MDS or AML. In addition, an artificial distinction between AML20-30 and AML30+ was made by regulatory agencies by initially restricting approval of azacitidine to AML20-30...
The molecular pathogenesis of myelodysplastic syndromes (MDS) is poorly understood. In order to expand our knowledge of genetic defects in MDS, we determined the overall profile of genes expressed in bone marrow from patients with refractory anemia with excess blasts (RAEB) by serial analysis of gene expression (SAGE). The present report describes a partial transcriptome of RAEB bone marrow der...
Clinics and pathology Disease Myeloid disorders: Myelodysplastic syndrome ( MDS ) type refractory anemia (RA) (Wlodarska et al., 1995) and refractory anemia with excess blasts (RAEB) (Struski et al., 2008). Philadelphia chromosome positive chronic myeloid leukemia (CML) in transformation (Aguiar et al., 1997). Etiology Only 3 cases so far; 77-year old male (MDS-RA) and 71-year old female (MDS-R...
Pediatric myelodysplastic syndrome (MDS) is a heterogeneous disease covering a spectrum ranging from aplasia (RCC) to myeloproliferation (RAEB(t)). In adult-type MDS there is increasing evidence for abnormal function of the bone-marrow microenvironment. Here, we extensively studied the mesenchymal stromal cells (MSCs) derived from children with MDS. MSCs were expanded from the bone-marrow of 17...
The goal of this study was to explore the plasma proteome of myelodysplastic syndrome (MDS) patients with refractory anemia with excess blasts subtype 2 (RAEB-2) in comparison to healthy controls. 20 plasma samples were separated with 2D electrophoresis and statistically processed with Progenesis SameSpots software. 47 significantly differing (P < 0.05) spots were observed, and 27 different pro...
Classification The FAB and WHO classifications The French-American-British (FAB) cooperative group produced the first systematic attempt of a classification dividing myelodysplastic syndrome (MDS) into five subgroups: refractory anemia (RA), RA with ringed sideroblasts (RARS), RA with excess of blasts (RAEB), RAEB in transformation (RAEB-t), and chronic myelomonocytic leukemia (CMML)1;2. Distin...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید