background and objective: parkinson's disease (pd) is characterized by a progressive loss of dopaminergic neurons in substantia nigra. in recent years, there have been interests in the role of the free radical damage in pd. cinnamon and its derivative, cinnamaldehyde acts as powerful antioxidant and anti-inflammatory agents. this research focused on the effects of cinnamon extract and cinn...

Background and Objective: Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons in substantia nigra. In recent years, there have been interests in the role of the free radical damage in PD. Cinnamon and its derivative, cinnamaldehyde acts as powerful antioxidant and anti-inflammatory agents. This research focused on the effects of cinnamon extract and cinnamald...

Mitochondrial activity determines aging rate and the onset of chronic diseases. The mitochondrial permeability transition pore (mPTP) is a pathological in inner membrane thought to be composed F-ATP synthase (complex V). OSCP, subunit synthase, helps protect against mPTP formation. How destabilization OSCP may contribute aging, however, unclear. We have found that loss nematode Caenorhabditis e...

The mitochondrial permeability transition pore (mPTP) is a non-selective, large-conductance channel that is closed under physiological conditions. Opening of the mPTP, leading to abolition of mitochondrial functions, is a major mechanism of myocyte necrosis by ischaemia/reperfusion, and direct inhibition of mPTP opening by use of pharmacological or genetic manipulations limits infarct size in v...

Single-loop methods based on the Karush–Kuhn–Tucker conditions are considered to be efficient reliability design optimization (RBDO) methods. The probabilistic performance functions converted deterministic for reducing computational burden of analysis. However, most probable target point (MPTP) estimated using steepest descent search directions diverges or oscillates highly nonlinear functions....

Purpose: To study the potential neuroprotective effects of tanshinone IIA, a diterpene quinone, in an experimental model 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson disease (PD).
 Methods: Mice (C57BL/6) were administered freshly-prepared MPTP at dose 20 mg/kg body weight intraperitoneally, 4 times 2-h intervals, to induce PD. Doses 12.5, 25 and 50 IIA mice as ...