BACKGROUND Compound targeting histone deacetylase (HDAC) represents a new era in molecular cancer therapeutics. However, effective HDAC inhibitors for the treatment of solid tumors remain to be developed. METHODOLOGY/PRINCIPAL FINDINGS Here, we propose a novel HDAC inhibitor, N-Hydroxy-4-(4-phenylbutyryl-amino) benzamide (HTPB), as a potential chemotherapeutic drug for solid tumors. The HDAC ...

The Gram-negative intracellular pathogen Legionella pneumophila replicates in a membrane-bound compartment known as the Legionella-containing vacuole (LCV), into which it abundantly releases its chaperonin, HtpB. To determine whether HtpB remains within the LCV or reaches the host cell cytoplasm, we infected U937 human macrophages and CHO cells with L. pneumophila expressing a translocation rep...

Effects of hyperbranched polyesters on kinetics of the reaction between hydroxyl-terminated polybutadiene (HTPB) and isophorone diisocyanate (IPDI) were investigated. HTPB and IPDI were in-situ cured in the presence of two different hyperbranched polyesters, stearic acid ester-terminated hyperbranched polyester (SHPE) and acetate-terminated hyperbranched polyester (AHPE). The curing processes w...

The Legionella pneumophila chaperonin, high temperature protein B (HtpB), was discovered as a highly immunogenic antigen, only a few years after the identification of L. pneumophila as the causative agent of Legionnaires' disease. As its counterparts in other bacterial pathogens, HtpB did not initially receive further attention, particularly because research was focused on a few model chaperoni...

The effect of replacing hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) by octahydro-1,3,5,7-tetranitro-1,3,5,7tetrazocine (HMX) in HTPB-binder on the performance, sensitivity, thermal, and mechanical properties of the sheet explosive formulation has been studied. The maximum loading of HMX was achieved up to 78 per cent in HTPB-binder system. The velocity of detonation (VOD) of HMX-based sheet e...

A 60-kilodalton (kDa) immunodominant antigen of Legionella pneumophila is a heat shock protein (HSP) of the GroEL class of HSPs. The gene (htpB) coding the 60-kDa protein was localized to a 3.2-kilobase DNA fragment of L. pneumophila cloned into pUC19 (pSH16) (P. S. Hoffman, C. A. Butler, and F. D. Quinn, Infect. Immun. 57:1731-1739, 1989). The nucleotide sequence of the DNA fragment cloned int...

Diglycidyl ether of bisphenol-A (DGEBA), having number average molecular weight (Mn) 375, was modified by incorporating the hydroxyl terminated polybutadiene (HTPB) based prepolymer using isophorone diisocyanate as a coupling agent. To increase the compatibility between the epoxy resin and HTPB part, polar groups were introduced in the later to achieve physical and chemical interactions between...

Aluminum hydride (AlH3) is a promising replacement for aluminum in hybrid and solid propellants, where hydroxyl-terminated polybutadiene (HTPB) normally used as binder. In this study, reactive molecular dynamics simulation method employed to investigate the fundamental oxidation mechanisms of AlH3/HTPB fuel using core-shell nanoparticle configuration. The overall found proceed three distinctive...