سابقه و هدف: سلامت خاک از مولفه ‏های اصلی در دستیابی به سامانه ‏‏های کشاورزی پایدار بوده که شدت تحت تاثیر عملیات زراعی مانند خاکورزی قرار می ‏گیرد. را توان با استفاده پارامترهای فیزیکی، شیمیایی بیولوژیکی قالب الگوریتم‏ های مشخص کمّی کرد. نتیجه، بررسی وضعیت کیفی باروری مدیریتی مختلف زمین جهت استقرار مناسب برای تولید بهینه نظام‌های امری ضروری می‏ باشد. چارچوب ارزیابی مدیریت SMAF 1 عنوان ابزاری قدر...

Background and Aims: Detection of overexpression in tumor-inhibiting genes provides valuable information for leukemia diagnosis and prognosis. Chronic myeloid leukemia (CML) is a stem cell disorder determined by a well-defined genetic anomaly involving BCR-ABL translocation in the Philadelphia chromosome. Curcumin is a chemo-preventive agent for the primary cancer targets, such as the breast, p...

Objective(s): Chronic myeloid leukemia (CML) is a myeloid clonal proliferation disease defining by the presence of the Philadelphia chromosome that shows the movement of BCR-ABL1. In this study, the critical role of the Musashi2-Numb axis in determining cell fate and relationship of the axis to important signaling pathways such as Hedgehog and Notch that are essential ...

The Breakpoint Cluster Region is a protein encoded by the BCR gene with its partially discovered function to generate instructions for producing and also encode serine/threonine kinase protein. There are three cluster regions; major (M-bcr) which high in CML patients, minor (m-bcr) 1-2% contribution CML, micro (μ-bcr) very rare case of CML. ABL1 encodes can as tyrosine kinase. translocation ABL...

Background: RNA interference (RNAi) is the mechanism of gene silencing-mediated messenger RNA degradation by small interference RNA (siRNA), which becomes a powerful tool for in vivo research, especially in the areas of cancer. In this research, the potential use of an expression vector as a specific siRNA producing tool for silencing of Bcr-abl in K562 cell line has been investigated. Methods:...