BACKGROUND AND AIMS Although inflammatory and hormonal markers have been associated with further functional adverse outcomes in community- dwelling seniors, these markers have not been studied from this perspective in acutely ill older patients. This prospective study was designed to determine whether biological markers can improve the predictive value of a clinical screening tool to assess the...

Purpose To introduce SHERPA-LEAP, a model for the consortial development, population and support of eprints repositories. Design/methodology/approach The organisational and technical structures of the consortium are described, including a brief summary of central and local resource responsibilities. Some positive and negative aspects of a consortial approach to institutional repository developm...

Birth weight (BW) is an important determinant of infant's well being. Several factors such as mothers' genetic characteristics, socio-cultural, demographic, behavioral factors, prepregnancy body mass index (BMI), gestational weight gain (GWG) etc contribute to birth weight. This study assesses the anthropometric measurement of ethnic Nepalese women belonging to Sherpa/Tamang community and Brahm...

The Sherpa population in Tibet is world-renowned for their extraordinary high-altitude fitness, as most famously demonstrated by Tenzing Norgay’s ability to conquer Mount Everest alongside Sir Edmund Hillary. The genetic adaptation behind this fitness has been a topic of hot debate in human evolution, with recent full genome sequencing efforts completed to look for candidate genes necessary for...

This paper introduces the idea of predicting ‘designer error’ by evaluating devices using Human Error Identification (HEI) techniques. This is demonstrated using Systematic Human Error Reduction and Prediction Approach (SHERPA) and Task Analysis for Error Identification (TAFEI) to evaluate a vending machine. Appraisal criteria which rely upon user opinion, face validity and utilisation are ques...

We report on the first next-to-leading order QCD computation of W+3-jet production in hadronic collisions including all partonic subprocesses. We compare the results with data from the Tevatron and find excellent agreement. The required one-loop matrix elements are computed using on-shell methods, implemented in a numerical program, BlackHat. We use the SHERPA package to generate the real-emiss...

Short-term, high-altitude (HA) exposure raises pulmonary artery systolic pressure (PASP) and decreases left-ventricular (LV) volumes. However, relatively little is known of the long-term cardiac consequences of prolonged exposure in Sherpa, a highly adapted HA population. To investigate short-term adaptation and potential long-term cardiac remodeling, we studied ventricular structure and functi...

BACKGROUND In the Emergency Department (ED), early and rapid identification of older people at risk of adverse outcomes, who could best benefit from complex geriatric intervention, would avoid wasting time, especially in terms of prevention of adverse outcomes, and ensure optimal orientation of vulnerable patients. We wanted to test the predictive ability of a screening tool assessing risk of f...