Juvenile Huntington’s Disease (JHD) is a rare variant of the hereditary neurodegenerative disorder disease (HD). Clinical symptoms in JHD are broad and non-specific, making initial diagnosis difficult. In this report, we describe young Hispanic male who gradually developed cognitive decline, dystonia, seizures. His was delayed despite multiple visits to his pediatrician, developmental specialis...

BACKGROUND Huntington's disease (HD) is an autosomal dominant disorder, typically characterized by chorea due to a trinucleotide repeat expansion in the HTT gene, although the clinical manifestations of patients with juvenile HD (JHD) are atypical. CASE PRESENTATION A 17-year-old boy with initial presentation of tics attended our clinic and his DNA analysis demonstrated mutation in the HTT ge...

Jianpi Huayu Decoction (JHD), a Chinese medicine formula, is a typical prescription against multiple tumors in the clinical treatment, which can raise quality of life and decrease complications. The aim of this study is to assess the efficacy of JHD against human colorectal carcinoma cells (SW480) and explore its mechanism. MTT assay showed that JHD decreased the cellular viability of SW480 cel...

It may seem like everywhere we look, there is something wrong or “broken” in health care. Articles published The Journal of Health Design (The JHD) reflect 13 incredulous, yet unfortunately “sad” realities about the state care that are evident worldwide. There reason for hope, though, as important research and experiences JHD convey. Much can be done to improve patient experience, one story exp...

Background: The clinical presentation of Juvenile Huntington’s Disease (JHD) can be very different from adult-onset HD with little evidence to guide symptomatic management. Aim: To survey the current use of pharmacological treatments for JHD. Methods: Patients were identified through the HD Association, Hospital Doctors and the European Huntington’s Disease Network REGISTRY study. Results: The ...

In 2003, a massive hydraulic fracturing experiment was carried out at the European Geothermal Hot Dry Rock site at Soultz-sous-Forêts, France. The two week injection of water generated a high level of microseismic activity. About 90,000 microearthquakes were triggered during and after this fluid injection. Of these, 21,000 events, detected at all stations, were located individually with a grid ...

We recently showed that class I-restricted CD8+ T cells mediate clearance of primary rotavirus infection in mice: JHD knockout (JHD -/-) (B-cell-deficient) mice depleted of CD8+ T cells become chronically infected with murine rotavirus, and beta2 microglobulin knockout (beta2m -/-) mice have delayed but complete clearance of primary rotavirus infection. In the present work we have analyzed the ...

Jiedu Huoxue Decoction (JHD), a recommended traditional prescription for patients with severe COVID-19, has appeared in the treatment protocols China. Based on bioinformatics and computational chemistry methods, including molecular docking, dynamics (MD) simulation, Molecular Mechanics Generalized Born Surface Area (MM/GBSA) calculation, we aimed to reveal mechanism of JHD treating COVID-19. Th...

In visceral leishmaniasis, the draining LN (DLN) is the initial site for colonization and establishment of infection after intradermal transmission by the sand fly vector; however, little is known about the developing immune response within this site. Using an intradermal infection model, which allows for parasite visceralization, we have examined the ongoing immune responses in the DLN of BALB...