Granzyme-mediated cell death is the major pathway for cytotoxic lymphocytes to kill virus-infected and tumor cells. In humans, five different granzymes (i.e. GrA, GrB, GrH, GrK, and GrM) are known that all induce cell death. Expression of intracellular serine protease inhibitors (serpins) is one of the mechanisms by which tumor cells evade cytotoxic lymphocyte-mediated killing. Intracellular ex...

The objective of this study was to estimate the genetic variance for within-litter variation of birth weight (BW0) using genomic (GRM) or pedigree relationship matrices (PRM) and to compare the accuracy of estimated breeding values (EBV) for within-litter variation of BW0 using GRM and PRM. The BW0 and residual variance of BW0 were modeled by the double hierarchical generalized linear model usi...

GRM and PROVE were originally designed and implemented as part of the P-GRADE graphical parallel program development environment running on clusters. In the framework of the biggest European Grid project, the DataGrid project we investigated the possibility of transforming GRM and PROVE to a Grid monitoring infrastructure. This paper presents the results of this work showing how to separate GRM...

This paper presents a new theoretical model (the Generic Regulation Model GRM) which is aimed for e-government development. This model has evolved through an action research project in e-government. The project has worked in the area of personal assistance to disabled persons. In this project there was a need to conceptualize the relations between different governmental agencies and the clients...

GRM was originally designed and implemented as part of the P-GRADE graphical parallel program development environment running on supercomputers and clusters. In the framework of the biggest European Grid project, the DataGrid we investigated the possibility of transforming GRM to a grid application monitoring infrastructure. This paper presents the architectural redesign of GRM to become a stan...

The genomic relationship matrix (GRM) can be inverted by the algorithm for proven and young (APY) based on recursion on a random subset of animals. While a regular inverse has a cubic cost, the cost of the APY inverse can be close to linear. Theory for the APY assumes that the optimal size of the subset (maximizing accuracy of genomic predictions) is due to a limited dimensionality of the GRM, ...

Two GRMs were fitted using the method created by Zaitlen et al (2013). The first GRM comprised of pairwise relationship coefficients of all individuals in the sample. The second GRM included off-diagonal elements of pairs of individuals who has a relationship coefficient < 0.05 set to 0. Assuming inbreeding had not taken place, the second GRM excluded pairs of individuals with a most recent com...

For Generalized Reed-Muller, GRM(q, d, n), codes, the determination of the second weight is still generally insolved, it is an open question of Cherdieu Rolland [1]. In order to answer this question, we study some maximal hypersurfaces and we compute the second weight of GRM(q, d, n) codes with the restriction that q > 2d. 2000 Mathematics Subject Classification. 11T71, 14J70, 05B25.

Abstract We present the results of forced-vibration experiments performed at large-scale prototype structure EuroProteas founded on gravel-rubber mixture (GRM) layers acting as a means Geotechnical Seismic Isolation (GSI). Three GRM with different rubber content per weight (0%, 10%, and 30%) but same mean grain size ratio were used foundation soil. Each GRM-structure system was subjected to har...