Desirability functions (DF)s play an increasing role for solving the optimization of process or product quality problems having various quality characteristics to obtain a good compromise between these characteristics. There are many alternative formulations to these functions and solution strategies suggested for handling their weaknesses and improving their strength. Although the DFs of Derri...

A problem facing the product development community is developing simultaneous solutions of response variables (to several properties) that depends on a number independent or sets responses. Harrington, among others, addressed this and presented desirability function with functional approach. Derringer Suich altered their approach illustrated how multiple can be transformed into convenience func...

A problem facing the product development community is developing simultaneous solutions of response variables (to several properties) that depends on a number independent or sets responses. Harrington, among others, addressed this and presented desirability function with functional approach. Derringer Suich altered their approach illustrated how multiple can be transformed into convenience func...

The sample preparation of samples containing bovine serum albumin (BSA), e.g., as used in transdermal Franz diffusion cell (FDC) solutions, was evaluated using an analytical quality-by-design (QbD) approach. Traditional precipitation of BSA by adding an equal volume of organic solvent, often successfully used with conventional HPLC-PDA, was found insufficiently robust when novel fused-core HPLC...