PURPOSE A topical synthetic metalloproteinase inhibitor (SIMP) has been reported to reduce the incidence of corneal ulcerations in the alkali-injured eye by the putative mechanism of collagenase inhibition. The current study was performed to determine whether SIMP has a direct inhibitory effect on the activation of neutrophils and to compare any such effect with that of citrate, a known inhibit...

AIM To compare and contrast 3 different echocardiographic methods used to measure left atrial (LA) volume: biplane area length (AL), biplane modified Simpson (SIMP), and prolate ellipse (PE) methods. METHODS AND RESULTS A review of consecutive patients who presented to our outpatient echocardiography laboratory for a resting transthoracic study between April 2006 and May 2006 was performed. E...

This theory defines the type inference rules and the type inference algorithm W for MiniML (simply-typed lambda terms with let) due to Milner. It proves the soundness and completeness of W w.r.t. the rules. A report describing the theory is found in [1] and [2]. 1 Universal error monad theory Maybe imports Main begin definition option_bind :: "[’a option, ’a => ’b option] => ’b option" where "o...

For reliability-based topology optimization (RBTO) of double layer grids, a two-stage optimization method is presented by applying “Solid Isotropic Material with Penalization” and “Ant Colony Optimization” (SIMP-ACO method). To achieve this aim, first, the structural stiffness is maximized using SIMP. Then, the characteristics of the obtained topology are used to enhance ACO through six modific...

The area of topology optimization of continuum structures of which is allowed to change in order to improve the performance is now dominated by methods that employ the material distribution concept. The typical methods of the topology optimization based on the structural optimization of two phase composites are the so-called variable density ones, like the SIMP (Solid Isotropic Material with Pe...

Purpose. A topical synthetic metalloproteinase inhibitor (SIMP) has been reported to reduce the incidence of corneal ulcerations in the alkali-injured eye by the putative mechanism of coUagenase inhibition. The current study was performed to determine whether SIMP has a direct inhibitory effect on the activation of neutrophils and to compare any such effect with that of citrate, a known inhibit...