Trimethoprim (TMP) has been widely used since the 1960s, both alone and in combination with sulfamethoxazole. Unfortunately, information regarding the role that cytochrome P450 enzymes (P450s) play in the formation of TMP primary metabolites is scarce. Hence, we undertook in vitro studies to identify and more fully characterize the P450s that catalyze formation of six TMP primary metabolites: T...

Human plasma butyrylcholinesterase (BChE) contributes to cocaine metabolism and has been considered for use in treating cocaine addiction and cocaine overdose. TV-1380 is a recombinant protein composed of the mature form of human serum albumin fused at its amino terminus to the carboxy-terminus of a truncated and mutated BChE. In preclinical studies, TV-1380 has been shown to rapidly eliminate ...

Continual improvement of oxygenators has been important in the growing demands of patient safety and support during cardiopulmonary bypass. The purpose of this study was to compare the Maxima 1380 oxygenator to the upgraded Maxima Plus oxygenator. Thirty-two adult patients were randomized to either the 1380 group or the Plus group. Information was recorded on the patients' weight, age, body sur...

During the past several years, our laboratory has studied the mechanism of immune suppression in the 4-hydroxy-3-nitrophenyl acetyl (NP) 1 system. In this model system, both cell-mediated and humoral immunity (1-3) have been analyzed. The findings have permitted integration of the data into a single linear scheme of cellular interactions (3-5). Based on the results obtained in our and other lab...

Schaller on Archer ............................. 1379 Coruell on Archer .............................. 1380 Eagly on Archer ................................. 1380 Archer Replies ................................... 1383 Hojat on the U.N. Convention on the Rights of the Child ................ 1384 Wessells on the U.N. Convention on the Rights of the Child ............... 1385 Juni on Students' Ri...

The phytoplankton in warm oligotrophic regions of the open oceans is dominated by ,2-mm cells too small for efficient direct consumption by mesozooplankton. However, these primary producers are hypothetically linked to higher trophic levels via the cascading impacts of mesozooplankton grazing on intermediate consumers. To assess the magnitudes of these indirect trophic linkages, grazing experim...

(t,m) [894]. (t, n) [900]. $10.00 [995]. $12.00 [995]. 128 [1378]. $15.00 [999]. $16.95 [995]. $16.96 [1019]. $18.95 [988]. $24.00 [988]. $24.00/$34 [1019]. $24.95 [988, 1019]. $26.95 [1019]. $30.95 [995]. $45.00 [1009]. $5.95 [995]. $54.00 [1019]. $54.95 [988]. $54.99 [995]. $6.50 [988]. $6.95 [988]. $69.00 [988]. $69.95 [1019]. $75.00 [1019]. $89.95 [1321]. A [641]. A [1430, 1156]. χ [380]. k...