OBJECTIVE To examine whether long-term measures of cortisol predict Alzheimer disease (AD) risk. METHOD We used a prospective longitudinal design to examine whether cortisol dysregulation was related to AD risk. Participants were from the Baltimore Longitudinal Study of Aging (BLSA) and submitted multiple 24-hour urine samples over an average interval of 10.56 years. Urinary free cortisol (UF...

Using liquid chromatography, we estimated the urinary excretion of20a-dihydrocortisol (20-DH)and urinary freecortisol (UFC)innormalsubjects and in40 patients withCushing’s syndrome of different etiologies. The median normal excretion rate (nmol/24 h) was 174 for 20-DH and 68 for UFC, the 20-DH/UFC ratio thus being 2.55. For patients with Cushing’s syndrome, the excretion rate was 1798 for 20-DH...

First submission on 11/06/13; last submission on 13/11/13; accepted for publication on 19/11/13; published on 20/02/14 1. Doctorate in Biotechnology in Health from Rede Nordeste de Biotecnologia (Renobio)/Universidade Federal do Ceará (UFC); master’s degree in Medical Microbiology from UFC; professor of Medical Microbiology at the Medical School of UFC. 2. Doctorate in Pharmacology from UFC; ma...

OBJECTIVE Twenty-four-hour urinary free cortisol (UFC) sampling is commonly used to evaluate Cushing's syndrome. Because there are few data on UFC variability in patients with active Cushing's disease, we analysed baseline UFC in a large patient cohort with moderate-to-severe Cushing's disease and assessed whether variability correlates with hypercortisolism severity. These data will help clini...

Thermoplastic epoxy resin (TPER)-based composites containing different amounts of ultra-fine cellulose (UFC) were prepared via melt compounding and injection molding. The effect of UFC loading on the mechanical properties and dynamic rheological behavior of the UFC-filled TPER composites was analyzed. The UFC-filled composites displayed higher complex viscosities than those of the neat TPER com...

The 24-hour urinary excretion of 6-β-hydroxycortisol (6β-OHC) and the urinary ratio of 6β-hydroxycortisol/cortisol (6β-OHC/UFC) have been proposed as noninvasive probes for human cytochrome P450 3A4 isoform (CYP3A4). In this study, we evaluated withinand between-day variability of 6β-OHC excretion and 6β-OHC/UFC ratio in nine Caucasian men with cardiac disease. Each study participant was asked ...

Purpose: To compare the intraocular pressure (IOP) reducing effect and safety of fixed combination (FC) latanoprost/ timolol with unfixed combination (UFC) brimonidine/timolol in patients with increased IOP. Methods: In this 6 month, randomised, evaluator masked, parallel group European study, patients with glaucoma or ocular hypertension and IOP >21 mm Hg on monotherapy or .16 mm Hg on dual th...

CONTEXT Short sleep duration is associated with adverse health outcomes, but the mechanisms involved are unknown. It has been postulated that short sleep duration may elevate cortisol levels, but studies have had conflicting results. It is unclear whether these differing findings may be due to methodological issues, such as assessment of sleep duration. Specifically, objective versus subjective...

BACKGROUND Function of the hypothalamus-pituitary-adrenal (HPA) axis has been associated with several somatic and psychiatric health problems. The amount of free cortisol excreted in the urine during 24h (24-h UFC) has often been used as a proxy for HPA-axis function. Reference values for 24-h UFC and their stability in the short and long term, as well as sources of variability, are largely lac...

CONTEXT AND OBJECTIVE The role of cabergoline in Cushing's disease (CD) remains controversial. The experience is limited to case reports and few open studies that report the effects determined after ≥1 month of treatment. In prolactinomas and dopamine-responsive GH-secreting tumours, effects of cabergoline are seen within days or weeks. Here, we searched for short-term effects of cabergoline in...