Immortality is an essential characteristic of cancer cells; a recent transcriptomic study of epithelial cell immortalization has linked epigenetic silencing of the long noncoding RNA Mortal Obligate RNA Transcript (MORT; alias ZNF667-AS1) to this process. This study evaluated the epigenetic and transcriptional state of MORT in two premalignant conditions-ductal carcinomas in situ and colon aden...

Background: A foundational library called MORT (Molecular Objects and Relevant Templates) for the development of new software packages and tools employed in computational biology and computer-aided drug design (CADD) is described here. Results: MORT contains several advantages compared with the other libraries. Firstly, MORT written in C++ natively supports the paradigm of object-oriented desig...

Immortality is an essential characteristic of human carcinoma cells. We recently developed an efficient, reproducible method that immortalizes human mammary epithelial cells (HMEC) in the absence of gross genomic changes by targeting 2 critical senescence barriers. Consistent transcriptomic changes associated with immortality were identified using microarray analysis of isogenic normal finite p...

Professor Morton Kramer, age 84, died on August 17,1998, in Pikesville, Maryland, USA, near Baltimore. He is survived by three children and their families. He is remembered by hundreds of students, friends, and colleagues around the globe. As a young man, Mort was an enthusiastic scholar and student-athlete at Baltimore City College and Johns Hopkins University. While studying undergraduate che...

The Center for Ulcer Research and Education (CURE) from its onset was primarily the work of one man: Professor Morton Grossman, or "Mort" as he was known and called by all. Mort's legacy includes a large body of scientific publications, the first National Institutes of Health Digestive Diseases Center (CURE), and, most importantly, a group of scientists who have become academic leaders and who ...

The aim of this study was to determine the effect of animal management and farm facilities on total feed intake (TFI), feed conversion ratio (FCR) and mortality rate (MORT) of grower-finishing pigs. In total, 310 batches from 244 grower-finishing farms, consisting of 454 855 Pietrain sired pigs in six Spanish pig companies were used. Data collection consisted of a survey on management practices...

background accident investigation programs are a necessary part in identification of risks and management of the business process. objectives one of the most important features of such programs is the analysis technique for identifying the root causes of accidents in order to prevent their recurrences. analytical hierarchy process (ahp) was used to compare management oversight and risk tree (mo...

Example 1 (Motivation) Suppose MapleBank in Canada wants to investigate whether there is some orders which customers often follow to open their accounts. A database DB in Table 1 about four customers’ sequences of opening accounts in MapleBank is analyzed. Given a support threshold min sup, a sequential pattern is a sequence s which appears as subsequences of at least min sup sequences. For exa...