Pharmacological neuroenhancement (PNE) is a form of abuse and has not yet been addressed by methods of pharmacovigilance. In the present study, we tested if quantitative signal detection may be sensitive in regards to PNE. We evaluated the risk of drug abuse and dependence (DAAD) related to substances that are known to be used for PNE and divided this group into agents with (methylphenidate) an...

A series of structurally diverse spiro 1,3-oxazines were conveniently prepared from three-component reaction conjugated imines, dialkyl acetylenedicarboxylates (DAAD), and N,N'-disubstituted parabanic acids in dry dichloromethane without catalyst. Initially, various imines synthesized aniline derivatives with cinnamaldehyde. Subsequently, DAAD N,N'-substituted led to mixture the corresponding s...

Σ k Π k DIFFm(Σ p k ) coDIFFm(Σ p k ) P Σ p k m-tt P Σ p k m+1-tt BH(Σ k ) Supported in part by grants NSF-CCR-9322513, NSF-INT-9513368/DAAD-315-PRO-fo-ab, and NSF-INT9815095/DAAD-315-PPP-gü-ab, and a NATO Postdoctoral Science Fellowship from the DAAD’s “Gemeinsames Hochschulsonderprogramm III von Bund und Ländern” program. This report combines and extends each of technical reports corr-cs.CC/9...