BACKGROUND In the past "blood-brain barrier" agents such as Tc99m-glucoheptonate were routinely used for the diagnosis of brain tumours. Of late, agents used for studying myocardial perfusion namely, Tc99m-tetrofosmin, Thallium-201, and Tc99m-sestamibi have replaced the "blood-brain barrier agents " when imaging is undertaken for the detection of the recurrence of brain tumours. However, the in...

BACKGROUND AND OBJECTIVE The tracer tachnetium-99m-2-methoxy-isobutyl-isonitrile (Tc99m-sestaMIBI) has recently been shown to concentrate in some neoplastic tissues, including myeloma. We investigated the diagnostic capacity and limits of this procedure in tracing focal myeloma lesions, and compared them with those of conventional radiological procedures (Xr). DESIGN AND METHODS We studied 55...

The Ni atom in the title complex, (C(24)H(20)P)(2)[Ni(C(9)H(17)NO(2)S(3))(2)], lies on a twofold axis within a square-planar geometry defined by four S atoms derived from two dithio-carbimate dianions, each forming a four-membered chelate ring. A small distortion, described by a deviation of the Ni(II) atom by 0.083 (1) Å from the plane through the four S atoms, and also by the torsion angles a...

Crossed McMurry reactions of bifuran- or bithiophenedicarbaldehydes with bipyrroledicarbaldehydes have been studied for the first time. Only those porphycenic macrocycles derived from homocoupled McMurry products were formed. The results are explained by using both density functional theory and electron propagator computations to model the electron affinity of the dialdehyde starting materials....

Radionuclide Tc99m DTPA (Diethylenetriaminepenta Acetic Acid) renal imaging is being used to assist in the evaluation of overall GFR, the intra-renal transit time, the cortical transit time, response to frusimide injection, diagnosis of ATN and rejection in renal transplant cases. A study was conducted at PINSTECH in order to prepare DTPA kit locally and evaluate the labeling efficiency as well...

Different image techniques have been used to analyze mucociliary clearance (MCC) in humans, but current small animal MCC analysis using in vivo imaging has not been well defined. Bitter taste receptor (T2R) agonists increase ciliary beat frequency (CBF) and cause bronchodilation but their effects in vivo are not well understood. This work analyzes in vivo nasal and bronchial MCC in guinea pig a...

OBJECTIVE The aim of this study was to determine the safety and efficacy of adenosine Tc99m sestamibi myocardial perfusion study under controlled conditions and to correlate the adenosine Tc99m sestamibi perfusion defects and the coronary angiography in patients investigated for coronary artery disease. METHODS This prospective study included 122 consecutive patients who underwent adenosine T...

for the Assessment of Glioma Proliferation We read the interesting recent article by Kato et al concerning the assessment of glioma metabolic activity by positron-emission tomography (PET). The authors evaluated the type, grade, and proliferation index of 95 primary glioma cases by simultaneous [F] fluorodeoxyglucose (18F-FDG), C-methionine (MET) and C-choline (CHO) PET. Their results in astroc...