The work presented here discusses an ongoing research in constructing a knowledge representation system founded on CAAD document repositories and investigating the network of concepts constructed by CAAD research. The approach does not rely on conceptual models or theories about CAAD research, rather a formal semantics amenable to decidable reasoning on the corpus of research in CAAD. A web-bas...

BACKGROUND Recent data suggest that high-density lipoprotein cholesterol (HDL-C) levels are likely not in the causative pathway of atheroprotection, shifting focus from HDL-C to its subfractions and associated proteins. This study's goal was to determine which HDL phenotype was the better predictor of carotid artery disease (CAAD). METHODS AND RESULTS HDL-2 and HDL-3 were measured in 1725 par...

We investigated the relationships between paraoxonase genetic polymorphisms and essential hypertension in carotid artery atherosclerotic patients. The study included 353 Han participants and 240 Uighur participants from Xinjiang; they were further divided into two groups: essential hypertension with carotid artery atherosclerosis (CAAD group) and essential hypertension without carotid artery at...

This paper outlines a possible locus for knowledge-based systems in computer-aided architectural design education. It commences with a review of computer-aided architectural design and knowledge-based systems. It then proposes their use at various stages in CAAD education. Introduction There are a number of paradigms to consider in computer-aided architectural design education. We could think o...

The genes (caaD1 and caaD2) encoding the trans-3-chloroacrylic acid dehalogenase (CaaD) of the 1,3-dichloropropene-utilizing bacterium Pseudomonas pavonaceae 170 were cloned and heterologously expressed in Escherichia coli and Pseudomonas sp. strain GJ1. CaaD is a protein of 50 kDa that is composed of alpha-subunits of 75 amino acid residues and beta-subunits of 70 residues. It catalyzes the hy...

The genetic factors associated with carotid artery disease (CAAD) are not fully known. Because of its role in lipid metabolism, we hypothesized that common genetic variation in the very low density lipoprotein receptor (VLDLR) gene is associated with severe CAAD (>80% stenosis), body mass index (BMI), and lipid traits in humans. VLDLR was resequenced for variation discovery in 92 subjects, and ...

( R)- and ( S)-oxirane-2-carboxylate were determined to be active site-directed irreversible inhibitors of the cis-3-chloroacrylic acid dehalogenase ( cis-CaaD) homologue Cg10062 found in Corynebacterium glutamicum. Kinetic analysis indicates that the ( R) enantiomer binds more tightly and is the more potent inhibitor, likely reflecting more favorable interactions with active site residues. Pro...

CumInCAD is a cumulative index of publications related to 'Computer Aided Architectural Design' (CAAD). It includes bibliographic data of approximately 12K records, which were predominantly derived from CAAD-related conferences, such as ACADIA, ASCAAD, CAADRIA, eCAADe, SiGraDi and CAAD futures. A brief historical overview of almost two decades of collaboration between the University of Ljubljan...

Background and Purpose—Lipoprotein(a) [Lp(a)] level is an established risk factor for coronary artery disease and has been implicated in carotid artery disease (CAAD). The relationship between genetic variation in the LPA gene region and CAAD risk remains unknown. Methods—We genotyped single nucleotide polymorphisms (SNPs) in the LPAL2, LPA, and PLG regions in 530 individuals with severe CAAD a...