The human diarrheal pathogens Campylobacter jejuni and Campylobacter coli interfere with host innate immune signaling by different means, and their flagellins, FlaA and FlaB, have a low intrinsic property to activate the innate immune receptor Toll-like receptor 5 (TLR5). We have investigated here the hypothesis that the unusual secreted, flagellin-like molecule FlaC present in C. jejuni, C. co...

We conducted a prospective randomized trial to evaluate the ability of the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein, PIXY321, to ameliorate cumulative thrombocytopenia after multiple cycles of 5-fluorouracil, leucovorin, doxorubicin, cyclophosphamide (FLAC) chemotherapy compared with GM-CSF in patients with advanced breast cancer. Fifty-three patien...

Design earthquake ground motions for dynamic analyses are typically specified as outcrop motions, which may have to be modified for input at the base of a FLAC model. Often a ‘deconvolution’ analysis using a 1-D wave propagation code, such as the program SHAKE, is performed to obtain the appropriate input motion at depth. This seemingly simple analysis is often the subject of considerable confu...

Real-world applications routinely make authorization decisions based on dynamic computation. Rea-soning about dynamically computed authority is challenging. Integrity of the system might be compro-mised if attackers can improperly influence the authorizing computation. Confidentiality can also becompromised by authorization, since authorization decisions are often based on sensitive...

The models that were analyzed using FLAC version 4.0 (FLAC, 2000) are shown on Figure 5.1. The models have different soil types: loose silty sand with 20% fines content (Figures 5.1a and 5.1b), soft clay (Figure 5.1c), and silt (Figure 5.1d). Hence, the determination of the parameters is different for each model. The following sections discuss the determination of the parameters used in the ana...

The main goal of this research is to identify the system parameters of the dynamics of Rotor/Active Magnetic Bearing (Rotor/AMB) system employed in turbo molecular pumps (TMPs). The identification approach adopted in this work is based on experimental analysis and the application of Fuzzy Logic Adaptive ControlExtended Kalman Filter (FLAC-EKF). The estimation error for either system state or sy...

We present a method for detecting anomalies in vibration signals of wind turbine components. The predominant characteristics of wind turbine vibration signals are extracted by applying a time-frequency feature extraction method based on Fourier local autocorrelation (FLAC) features. For anomaly detection, one-class classification based on an unsupervised clustering approach is applied in consid...

A series of 102 transfer-deficient (tra(-)) mutants of Flac (84 of which have been previously described) were classified as carrying frameshift, amber, ochre, UGA, and nonsuppressible mutations. Techniques were evolved for using cultures of F prime strains as efficient recipients in matings, for measuring the number of (F'/F') heterozygote cells in transient populations, and for measuring compl...