Acquired resistance to the p.o. active lipophilic platinum drug bis-acetato-ammine-dichloro-cyclohexylamine platinum (i.v.) (JM216) was generated in the 41M and CH1 human ovarian carcinoma cell lines, and their resistance mechanisms were compared to parallel cisplatin-resistant (cisR) cell lines. Intracellular platinum accumulation was not reduced in either 41M/JM216R or CH1/JM216R compared to ...

We have compared the cellular accumulation and cytotoxicity of three platinum compounds in a panel of five human ovarian carcinoma cell lines. The cell lines, which were established from both untreated and pretreated patients, showed a wide range in sensitivity to cisplatin and other platinum drugs. The panel consisted of two sensitive (41M, CH1), one in vivo acquired resistant (PXN/94) with mo...

Acquired resistance to cisplatin has been generated in vitro in two human ovarian carcinoma cell lines: 41M, established from a previously untreated patient; and CH1, from a patient previously treated with cisplatin and cis-diammine-1,1-cyclobutane dicarboxylatoplatinum(II) (carboplatin). In neither cell line with acquired resistance did intracellular detoxification (via increased glutathione o...

We have compared the cellular accumulation and Cytotoxicity of three platinum compounds in a panel of five human ovarian carcinoma cell lines. The cell lines, which were established from both untreated and pretreated patients, showed a wide range in sensitivity to cisplatin and other platinum drugs. The panel consisted of two sensitive (41M, CHI), one in vivo acquired resistant (PXN/94) with mo...

Xylanase J (XynJ) from alkaliphilic Bacillus sp. 41M-1 is an alkaline xylanase. The crystal structure has been solved with XynJ. Improvement of the alkaliphily of XynJ was attempted by amino acid substitutions. Reinforcing the characteristic salt bridge in the catalytic cleft and introducing excess Arg residues on the protein surface shifted the optimum pH of the wild-type enzyme from 8.5 to 9.5.

مکان‌یابی با درنظرگرفتن موضوع رقابت در بازار، یک تصمیم راهبردی و بلندمدت محسوب می­‌شود. چنانچه انتخاب مکان، بررسی‌­های لازم صورت نگیرد، حیات سازمان تحت تأثیر قرار می‌­گیرد. به‌­دلیل وجود پیچیدگی‌­های موجود مسائل مکان‌یابی، ارائه مدل‌های محدودیت­‌های متنوعی مواجه است. هدف این پژوهش، توسعه مدل رقابتی درنظر­گرفتن دو محصول از سوی سه رقیب است؛ برای منظور، مسئله به‌­صورت بازی مکان ـ قیمت تعریف استفاد...

Acquired resistance to cisplatin has been generated in vitro in two human ovarian carcinoma cell lines: 41M, established from a previously untreated patient; and CHI, from a patient previously treated with cisplatin and cis-diammine-l,l-cyclobutane dicarboxylatoplatinum(II) (carboplatin). In neither cell line with acquired resistance did intracellular detoxification (via increased glutathione o...

Xylanase J of alkaliphilic Bacillus sp. strain 41M-1 contains a carbohydrate-binding module family 36 xylan-binding domain (XBD). Mutational analysis of the XBD revealed that Tyr237, Asp313, Trp317, and Asp318 were involved in Ca(2+)-dependent xylan-binding, and that Asp313 and Asp318 were especially important.

Abstract. Geographical processes might well impact online engagement in big countries like the USA. Upon a random sample of 200K news articles and corresponding 41M comments posted on the Yahoo! News in that country, we show that nearby individuals tend to comment and engage with similar news articles more than distant individuals do. Interestingly, at state level, topics one reads about are as...