Three systems of immunoradiometric assays (IRMAs), a two-site monoclonal antibody sandwich IRMA (MAb-IRMA), two-site polyclonal antibody-monoclonal antibody sandwich IRMA (PAb-MAb-IRMA), and two-site polyclonal antibody sandwich IRMA (PAb-IRMA), were developed to detect low-grade infections with Plasmodium falciparum. The assays showed good correlation with parasitemia when tested against paras...

To assess the clinical value of a sensitive immunoradiometric assay for TSH (IRMA-TSH), serum IRMA-TSH levels were compared with those of a radioimmunoassay (RIA-TSH) in twenty-eight patients with congenital hypothyroidism. Among 144 samples taken from them, 44 samples showed undetectable RIA-TSH, while only 10 samples were undetectable by IRMA-TSH. In two patients prospectively followed, RIA-T...

In this paper, we present our experience with the IRMA reliable multicast architecture. IRMA guarantees reliable, sequenced, and loosely synchronized delivery of multicast streams by supporting TCP as the multicast transport protocol at the end hosts without modifications to the standard TCP/IP stack. To support TCP as the multicast transport protocol, IRMA provides ACK aggregation, local recov...

The authors investigated immunoactive and bioactive follicle-stimulating hormone (FSH) secretion and clearance in six healthy young men during steady-state infusions of vehicle (basal, B, 28 hours), dihydrotestosterone (DHT, 4.5 days), or estradiol (4.5 days) accompanied by blood sampling at 10-minute intervals for 28 hours. Serum FSH concentrations were assayed by a two-site immunoradiometric ...

IRMA is a reliable multicast architecture that guarantees reliable, sequenced, and loosely synchronized delivery of multicast streams. IRMA provides ACK-based reliability, hybrid local server-initiated and sender-initiated loss recovery, and support for end-to-end flow control and congestion control. Unlike most contemporary work, IRMA supports TCP as the reliable multicast transport protocol a...

Tissue polypeptide antigen, measured by both a polyclonal antibody (TPA IRMA Prolifigen) and a monoclonal antibody prototype kit (TPA-M IRMA Prolifigen), and the tissue polypeptide specific antigen were evaluated. The markers were measured in 266 serum samples and in 291 tumour cytosols from patients with primary breast cancer. The three markers were available in matched pairs of both serum and...

Transmitting digital information using ultra-short pulses, impulse radio (IR) has received increasing interest for multiple access (MA). When IRMA systems have to operate in dense multipath environments, the multiple user interference (MUI) and intersymbol interference (ISI) induced, adversely affect system capacity and performance. Analog IRMA utilizes pulse position modulation (PPM) and rando...

We evaluated a new commercially available two-site immunoradiometric assay (IRMA; BioMérieux 125I-EPO CoatRIA) for erythropoietin (EPO) in human serum. The precision (CV) was 4.1% intra-assay and 8% interassay for a serum pool with an EPO concentration of 17 int. units/L; the detection limit was 0.5 int. unit/L, one order of magnitude lower than by classical radioimmunoassay (RIA), although sta...