Corresponding author: Agnieszka Dobrowolska-Redo 2nd Department of Obstetrics and Gynecology, Warsaw Medical University Karowa St. 2, 00–315 Warsaw, Poland tel.: +48 22 5966 421, fax: +48 22 5966 487, e-mail: [email protected] Non-simultaneous two-stage detection of spontaneous bilateral isthmic tubal pregnancy Agnieszka Gardyszewska1, Agnieszka Dobrowolska-Redo1, Krzysztof Cz...

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A novel mibefradil derivative, NNC55-0396, designed to be hydrolysis-resistant, was shown to be a selective T-type Ca(2+) channel inhibitor without L-type Ca(2+) channel efficacy. However, its effects on cytochromes P450 (P450s) have not previously been examined. We investigated the inhibitory effects of NNC55-0396 toward seven major recombinant human P450s--CYP3A4, CYP2D6, CYP1A2, CYP2C9, CYP2...

Mibefradil (Posicor) was developed as a calcium channel blocker for the treatment of chronic hypertension. The compound was withdrawn from the market in 1998 because of the potential for rhabdomyolysis, renal failure, or bradycardia when it was coadministered with other drugs. Mibefradil has previously been shown to be a potent reversible (IC(50) = 0.3-2 μM) and mechanism-based (K(i) = 2.3 μM; ...

The nucleotide sequence (5966 nucleotides) of cDNA clones of strawberry mild yellow edge-associated potexvirus was determined. The genome contains six open reading frames (ORFs) encoding putative proteins with Mrs of 149,423, 25,344, 11,576, 8079, 25,714 and 11,216. In the first three putative proteins and the coat protein considerable similarity was found to comparable polypeptides of the pote...

1. Name of Host Institution: Memorial Sloan-Kettering Cancer Center 2. Program Subspecialty: Pediatric Neuro-Oncology 3. Program Address (mailing): Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 565, New York, NY 10065 4. Program Address (physical location): Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065 5. Program Phone Number: (212) 639-5966 6. Program E...