This study investigated the effects of switching from combination therapy with either alogliptin (Alo) or pioglitazone (Pio) to fixed-dose combination therapy (FDCT) with alogliptin and pioglitazone (Alo-Pio FDCT). The usefulness and efficacy of Alo-Pio FDCT were investigated. A total of 50 outpatients with type 2 diabetes mellitus (T2DM) treated with Alo and 47 outpatients with T2DM treated wi...

Cholesterol-dependent cytolysins (CDCs) are secreted, pore-forming toxins that are associated with pathogenesis in a variety of gram-positive bacteria. Bacillus anthracis produces anthrolysin O (ALO), a CDC that is largely responsible for the hemolytic activity of culture supernates when the bacterium is cultured in appropriate conditions. B. cereus and B. thuringiensis, species closely related...

Abstract: In this work, the most common problem of the modern power system named optimal power flow (OPF) is optimized using the novel meta-heuristic optimization algorithm ant lion optimizer (ALO). ALO is inspired by the hunting process of ant-lions in the natural environment. ALO has a fast convergence rate due to the use of roulette wheel selection method. For the solution of the optimal pow...

BACKGROUND AND OBJECTIVE Given the dual public health challenges of undertreated pain and opioid abuse, there is a need to reduce attractiveness of opioid analgesics to drug abusers. ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules, indicated for treatment of chronic, moderate to severe pain, contain polymer-coated pellets of morphine, each with a core of sequest...

We demonstrate that single-crystal hexagonal GaN can be grown by metal-organic chemical vapor deposition on an aluminum oxide compound (AlO x ) layer utilized as an intermediate layer between GaN and a Si(1 1 1) substrate. The surface morphology of GaN grown on the AlO x /Si(1 1 1) substrate is found to be very sensitive to both the GaN buffer-layer thickness and the AlO x thickness. Contact mo...

“You old people get out and do something!” The advice comes from Felimina Rotundo, who runs a laundry shop in Buff alo, NY, USA. She turned a hundred on Oct 20, 2015, and has been “doing something”—working 11 hours a day, 6 days a week, from dawn to dusk—for the past 85 years. “I talk to people all day”, she tells the journalists gathered in the doorway of her shop. “I get up in the morning and...

We characterized the expression of a putative toxin of Bacillus anthracis, a member of the cholesterol-dependent cytolysin (CDC) family, which includes listeriolysin O, perfringolysin O, and streptolysin O. We named this cytotoxin anthrolysin O (ALO). Although B. anthracis expresses minimal hemolytic activity in clinical settings, we show that Sterne strain 7702 expresses hemolytic activity whe...

A retention behavior model for self-rectifying TaO/HfO x - and TaO/AlO x -based resistive random-access memory (RRAM) is proposed. Trapping-type RRAM can have a high resistance state (HRS) and a low resistance state (LRS); the degradation in a LRS is usually more severe than that in a HRS, because the LRS during the SET process is limited by the internal resistor layer. However, if TaO/AlO x el...