The receptor-like protein tyrosine phosphatase CD45 is expressed on the surface of cells of hematopoietic origin and has a pivotal role for the function of these cells in the immune response. Here we report that following infection of macrophages with mouse cytomegalovirus (MCMV) the cell surface expression of CD45 is drastically diminished. Screening of a set of MCMV deletion mutants allowed u...

Title of Document: ISOLATION AND CHARACTERIZATION OF A SPONGE-ASSOCIATED ACTINOMYCETE THAT PRODUCES MANZAMINES Olivier Peraud, Doctor of Philosophy, 2006 Directed By: Professor Russell T. Hill Marine Estuarine Environmental Sciences Two Indonesian sponges, Acanthostrongylophora sp. Sponge 35 and Sponge 52, containing manzamine A were collected off the coast of Manado, Indonesia. Manzamines are ...

We present HST Wide-Field Camera images of a field in the Orion Nebula obtained in emission from [S II], Hp, and [0 II]. The morphology of the [S II] emission is markedly different from the other lines. While HP and [0 II] are distributed fairly smoothly, [S II] is dominated by filamentary features with widths between 0':1 and 1" which sharply highlight ionization fronts moving into dense neutr...

A lac promotor mutant was constructed by filling in the protruding ends of the HpaII site located within the lac promotor. The mutation, named M42, is a two base pair insertion that changes the distance between the -10 and -35 regions from 18 to 20 residues. The activity of the mutant promotor measured in vivo is 15% of the wild-type promotor. The M42 promotor is sensitive to the catabolite rep...

Several aminopeptidases of the M42 family have been described as tetrahedral-shaped dodecameric (TET) aminopeptidases. A current hypothesis suggests that these enzymes are involved, along with the tricorn peptidase, in degrading peptides produced by the proteasome. Yet the M42 family remains ill defined, as some members have been annotated as cellulases because of their homology with CelM, form...

New innovative ways to increase the capacity of motorways in the UK, without the need for substantial landtake and construction, are currently being developed by the Highways Agency (HA). One of these methods is Hard Shoulder Running (HSR), piloted on the M42 from late 2006. Based on interviews and content analysis of media reports, conducted before the piloting of the M42 scheme, this paper ou...

Dasotraline is a dopamine and norepinephrine reuptake inhibitor, and the early clinical trials show a slow absorption and long elimination half-life. To investigate the absorption, distribution, metabolism, and excretion of dasotraline in humans, a single dose of [14C]-dasotraline was administered to eight healthy male adult volunteers. At 35 days, 90.7% of the dosed radioactivity was recovered...