Parkinson's disease is one of the most common neurodegenerative disorders. There are many documents about the effects of oxidative stress in Parkinson's disease etiology. Angiotensin II activates NADPH dependent oxidases and causes superoxides formation. Peganum harmala L. extract, which has angiotensin converting enzyme (ACE) inhibitory effect, is considered to evaluate oxidative stress inhibi...

Peganum harmala and Piper longum medicinal herbs are used in traditional medicine to treat various diseases and to relieve tragic processes. The chemical composition of these two compounds is their analgesic agent. The purpose of this study was the Peganum harmala and Piper longum rubbing oil effect on pain in male mice by using formalin test. In this study, male mice were divided into three gr...

Parasites of the genus Leishmania are transmitted by sandflies that ingest the parasite in the amastigote stage resident within macrophages, then inoculate the promastigote stage into other hosts. Peganum harmala, or Syrian Rue, has pharmacologically active compounds including several alkaloids with antiprotozoal properties, which are found especially in the seeds and the roots. In this researc...

The aim of this study was to find out the nutritional value of some selected plants of family Zygophyllaceae and Euphorbiaceae which are traditionally used in different parts of Pakistan. The five plants Fagonia cretica L., Peganum harmala L., Tribulus terrestris L., Chrozophora tinctoria (L.) Raf. and Ricinus communis L., were collected from Peshawar and Attock Hills during winter, 2009. In th...

Cancers and hepatoprotective prevention using traditional medicines have attracted increasing interest. The aim of our study was to characterize the putative protective effects of ethanol and chloroform extracts of Peganum harmala on thiourea-induced diseases in adult male rat. We seek to determine the effects of these plant extracts on body weight, thyroid and endocrine cancer parameters. In a...

Peganum harmala L. is a plant widely distributed in the Mediterranean region. It is commonly used in traditional medicine in Morocco as sedative and abortifacient but exposes users to the risk of overdose and poisoning. The pharmacologically active compounds of this plant include a number of β -carboline and quinazoline alkaloids responsible of its pharmacological and toxicological effects. We ...

Bioactivity-guided fractionation was used to determine the cytotoxic alkaloids from the toxic plant Peganum harmala. Two novel indole alkaloids, together with ten known ones, were isolated and identified. The novel alkaloids were elucidated to be 2-(indol-3-yl)ethyl-α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside (2) and 3-hydroxy-3-(N-acetyl-2-aminoethyl)-6-methoxyindol-2-one (3). The cytotoxi...

The seeds of Peganum harmala L. (Pgh) (Zygophyllaceae) have been used in Moroccan traditional medicine to treat various diseases. The objective of this study was to investigate the analgesic effect of ethyl acetate (EAE), butanolic (BE) and aqueous (AqE) extracts of seeds of Peganum harmala and to elucidate the possible action mechanism of each extract. The antinociceptive action was assayed in...

The statistical analysis revealed that 10g and 20g extracts of all the tested plants significantly inhibited the growth of Lemna minor with significant differences. The plants means were non-significant while the interaction between extracts and plants was significant. Fagonia cretica, Peganum harmala, Tribulus terrestris, Chrozophora tinctoria and Ricinus communis caused significant growth inh...