We have seen previously that there are three ways of generating new redexes by reduction. Out of the three forms, one may argue that one of them is not a new redex, but a residual of a redex in the initial term: We can define a new reduction which reduces this 'hidden redexes'. This reduction is called generalized β-reduction and is denoted by → g β. Given a term with hidden redexes, one step o...

Proteins reach the plasma membrane through the secretory pathway in which the trans Golgi network (TGN) acts as a sorting station. Transport from the TGN to the plasma membrane is maintained by a number of different pathways that act either directly or via the endosomal system. Here we show that a subset of cargoes depends on the ArfGAP2/3 Glo3 and ergosterol to maintain their proper localizati...

Arranged by Yarom Gabay based on a seminar by Assaf Kfoury March 1, 2005 The references are to Barendregt’s book [1]. So far we have studied the λ-calculus as a rewrite-system , i.e., we have studied properties of reduction, specifically, β-reduction. We can also study the λ-calculus as an equational theory , i.e., an axiomatic system consisting of axioms and inference rules to produce valid eq...

ةـصلاخلا : ةلاحلا رايعم ثحبلا اذه يف ضرعن – ةلاحلا حشرمُــل لماشلا يبراقتلا تابثلل غارفلا – يمقرلا غارفلا عبشملا يباسحلا ضئافلا مادختساب كلذو ةددحم ةميق اذ . دقو ماظنلل ةديدج ةيصاخ ءاصقتساب رايعملا قُـتشأ ةساردلا ديق . اس رايعم عم رايعملا اذه ةنراقمب انمق امآ جنيسو راآ نم لٍآ لَـبـقِ نم هضرع مت قب . دقو جنيسو راآ رايعم نم لقأ طباوض يذ يلاحلا رايعملا نأ ةنراقملا تنابأ . و نع حرتقملا رايعملا ةعاجن ان...

Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-translational modification. However, a potent and selective inhibitor targeting the SUMO pathway has been lacking. Here we describe ML-792, a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays. ML-792 selectively blocks SAE enzyme activity and total SUMOyl...