نتایج جستجو برای: آنالیز nbo

تعداد نتایج: 42184  

Journal: :Neuroscience letters 2007
Christopher Beynon Li Sun Hugo H Marti Sabine Heiland Roland Veltkamp

Hyperbaric (HBO) and normobaric (NBO) oxygen therapy have been shown to be neuroprotective in focal cerebral ischemia. In previous comparative studies, NBO appeared to be less effective than HBO. However, the experimental protocols did not account for important advantages of NBO in the clinical setting such as earlier initiation and prolonged administration. Therefore, we compared the effects o...

Journal: :Brain research 2016
Yash Vardhan Tiwari Zhao Jiang Yuhao Sun Fang Du Pavel Rodriguez Qiang Shen Timothy Q Duong

In order to improve clinical trial design and translation of normobaric oxygen (NBO) treatment of ischemic stroke, NBO treatment parameters need to be better understood. This study investigated NBO treatment efficacy at two different stroke severities and two NBO treatment durations in rats. For the 60-min middle cerebral artery occlusion (MCAO), NBO treatment for 25 min and 150 min were studie...

2012
Ona Wu Thomas Benner Luca Roccatagliata Mingwang Zhu Pamela W Schaefer Alma Gregory Sorensen Aneesh B Singhal

BACKGROUND Voxel-based algorithms using acute multiparametric-MRI data have been shown to accurately predict tissue outcome after stroke. We explored the potential of MRI-based predictive algorithms to objectively assess the effects of normobaric oxygen therapy (NBO), an investigational stroke treatment, using data from a pilot study of NBO in acute stroke. METHODS The pilot study of NBO enro...

Journal: :Stroke 2007
Aneesh B Singhal Eva Ratai Thomas Benner Mark Vangel Vallent Lee Walter J Koroshetz Pamela W Schaefer A Gregory Sorensen R Gilberto Gonzalez

BACKGROUND AND PURPOSE Recent studies suggest that normobaric oxygen therapy (NBO) is neuroprotective in acute ischemic stroke. METHODS We performed multivoxel magnetic resonance spectroscopic imaging and diffusion/perfusion MRI in patients with stroke treated with NBO or room air. Imaging was performed before, during, and after therapy. RESULTS Voxel-based analysis showed excellent correla...

2016
Pavel Rodriguez Jiang Zhao Brian Milman Yash Vardhan Tiwari Timothy Q. Duong

INTRODUCTION Ischemic stroke is a global burden that contributes to the disability and mortality of millions of patients. This study aimed to evaluate the efficacy of combined MB (methylene blue) and NBO (normobaric hyperoxia) therapy in experimental ischemic stroke. METHODS Rats with transient (60 min) MCAO (middle cerebral artery occlusion) were treated with: (1) air + vehicle (N = 8), (2) ...

Journal: :Stroke 2011
Norio Fujiwara Emiri T Mandeville Xiaokun Geng Yumin Luo Ken Arai Xiaoying Wang Xunming Ji Aneesh B Singhal Eng H Lo

BACKGROUND AND PURPOSE Normobaric oxygen (NBO) therapy may be neuroprotective in acute ischemic stroke. However, how NBO may affect intracerebral hemorrhage is unclear. We tested NBO in a rat model of striatal intracerebral hemorrhage. METHODS Intracerebral hemorrhage was induced by stereotactic injection of collagenase Type VII (0.5 U) into the right striatum of male Sprague-Dawley rats. One...

2014
Zhongrui Yuan Rong Pan Wenlan Liu Ke Jian Liu

BACKGROUND Normobaric hyperoxia (NBO) therapy is neuroprotective in acute ischemic stroke. However, how long the NBO should last to obtain optimal outcome is still unclear. Reports show that ischemic penumbra blood supply may remain compromised for a long period after ischemia-reperfusion, which would impair tissue oxygenation in ischemic penumbra. Therefore, we hypothesized that longer-lasting...

Journal: :Journal of applied physiology 2012
H N David B Haelewyn M Degoulet D G Colomb J J Risso J H Abraini

The potential benefit of 100 vol% normobaric oxygen (NBO) for the treatment of acute ischemic stroke patients is still a matter of debate. To advance this critical question, we studied the effects of intraischemic normobaric oxygen alone or in combination with recombinant tissue-plasminogen activator (rtPA) on cerebral blood flow and ischemic brain damage and swelling in a clinically relevant r...

2015
John Weaver Ke Jian Liu

Stroke, one of the most debilitating cerebrovascular and nuerological diseases, is a serious life-threatening condition and a leading cause of long-term adult disability and brain damage, either directly or by secondary complications. Most effective treatments for stroke are time dependent such as the only FDA-approved therapy, reperfusion with tissue-type plasminogen activator; thus, improving...

2016
Shu-Hai Shi Zhi-Feng Qi Yu-Min Luo Xun-Ming Ji Ke Jian Liu

Acute ischemic stroke is a common and serious neurological disease. Oxygen therapy has been shown to increase oxygen supply to ischemic tissues and improve outcomes after cerebral ischemia/reperfusion. Normobaric hyperoxia (NBO), an easily applicable and non-invasive method, shows protective effects on acute ischemic stroke animals and patients in pilot studies. However, many critical scientifi...

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