B acute lymphoblastic leukemia (B-ALL) cells are distinctively vulnerable to endoplasmic reticulum (ER) stress. Recently, inhibition of p97 was shown to induce ER stress and subsequently cell death in solid tumors and in multiple myeloma. We investigated the role of a novel, orally available, p97 inhibitor (CB-5083; Cleave Biosciences) in B-ALL. CB-5083 induced a significant reduction in viabil...

B4C ceramic particulate–reinforced Al 5083 matrix composite with various B4C content was fabricated successfully via hot-press sintering under Argon atmosphere. B4C particles presented relative high wettability, bonding strength and symmetrical distribution in the Al 5083 matrix. The hardness value, friction coefficient and wear resistance of the composite were higher than those of the Al 5083 ...

5083 aluminum alloy is a light-weight and strain-hardened material used in high strain-rate applications such as those experienced under shock loading. Symmetric real-time (in situ) and end-state (ex situ recovery) plate impact shock experiments were conducted to study the spall response and the effects of microstructure on the spall properties of both 5083-H321 and 5083-ECAE ? 30 % cold-rolled...

The constraint effect is the key issue in structural integrity assessments based on two parameter fracture mechanics (TPFM) to make a precise prediction of the load-bearing capacity of cracked structural components. In this study, a constraint-based failure assessment diagram (FAD) was used to assess the fracture behavior of an Al 5083-O weldment with various flaws at cryogenic temperature. The...

Al 5083 alloy powder was mechanically milled in liquid nitrogen to achieve a nanocrystalline (NC) structure having an average grain size of 50 nm with high thermal stability, and then consolidated by quasi-isostatic (QI) forging. The consolidation resulted in ultrafine grains (UFG) of about 250 nm, and the bulk material exhibited enhanced strength compared to conventionally processed Al 5083. T...

aluminum alloys such as al 5083 have primary potential for lightweight structural application in automotive and aerospace industries. this paper addresses the mechanical and tribological properties and corrosion resistance of chromium nitride coatings deposited on al 5083 that can be used for development of applications of aluminum 5083 alloy. the crn coatings of 1 μm thickness were deposited b...

5083 Meshik, A., Mabry, J, Hohenberg, C., Marrocchi, Y, Pravdivtseva, O., Burnett, D, Ollinger, C., Wiens, R., Reisenfeld, D., Allton, J., McNamara, K, Stansbery E, & Jurewicz A.(2007) Constraints on Neon and Argon isotopic fractionation in solar wind. Science

1Biomedical Signal and Image Processing Laboratory (BiSIPL), School of Electrical Engineering, Sharif University of Technology, P.O. Box 11365-9363, Tehran, Iran 2Laboratoire des Images et des Signaux (LIS), CNRS UMR 5083, INPG, UJF, 38031 Grenoble Cedex, France 3Laboratory for Computational Physiology, Harvard-MIT Division of Health Sciences and Technology (HST), Massachusetts Institute of Tec...