Malignant pleural mesothelioma is a poorly treated neoplasia arising from the pleural mesothelial lining. Here we document that the leaf extract of Cynara scolymus exerts broad antitumoral effects both in vitro and in vivo on mesothelioma cell lines. We found that Cynara scolymus treatment affects strongly cell growth, migration and tumor engraftment of mesothelioma cell lines. Strikingly, diet...

Background. Based on recent basic and clinical investigations, the extract of artichoke (Cynara scolymus) leaf has been revealed to be used for hepatoprotective and cholesterol reducing purposes. We aimed to assess the therapeutic effects of artichoke on biochemical and liver biomarkers in patients with nonalcoholic steatohepatitis (NASH). Methods. In a randomized double blind clinical trial, 6...

Cynara scolymus L. is a medicinal plant frequently used in traditional medicine for liver diseases. The aim of this study is to evaluate the antimicrobial activity of the different parts of Artichoke. Maximum antimicrobial activity was observed with methanolic extract of bound phenols for (bract and heart) against Gram negative bacteria. The MIC values for bound phenols from heart were (63μg/ml...

Effect of Methanol and Titanium Dioxide Nanoparticles on Phytochemical Properties Artichoke (Cynara scolymus L.)

The artichoke by-products from the canning industry are mainly used for silage, being minimally revaluated. The ways of extraction of by-products of artichoke into fiber-rich powders modify their industrial applications in biscuits, as the sensory evaluation may change compared with the reference fiber (Pea fiber, P) used with commercial biscuit. In this sensory study biscuits enriched with fib...

This study aimed to evaluate in-vitro antioxidant activities of hydroethanolic extract of leaves of Cynara scolymus L., Cupressus sempervirens L., and Eugenia jambolana Lam comparing with ascorbic acid, and their correlation with in-vivo hepatoprotective activity in rat model of paracetamol-induced hepatotoxicity, comparing with silymarin as reference agents. In-vitro study revealed that the te...

Cynara genus, originating from the Mediterranean area, includes globe artichoke (Cynara cardunculus var. scolymus L) and cardoon (Cynara cardunculus var. altilis DC). Traditionally these crops have long been used as food and medicine. Nowadays, they are considered as functional foods, owing to their nutritional properties. Artichoke has exhibited hepatoprotective and antioxidative activities, a...

The artichoke (Cynara cardunculus L. subsp. scolymus L.), the cultivated cardoon (Cynara cardunculus var. altilis DC.) and the wild cardoon (Cynara cardunculus var. sylvestris L.) are species widely distributed in the Mediterranean area. The aim of this research was to evaluate the antioxidant properties of seeds from lines of artichoke and cultivated and wild cardoon in both aqueous-organic ex...

BACKGROUND This paper assesses the current ethnobotanical knowledge, use and management of Scolymus hispanicus L. in two localities of Central Spain and the relation with its natural abundance. It also addresses the influence of sociodemographic factors such as age, gender and time living in the village in the variation of knowledge and practice levels. METHODS During 2007 and 2008, 99 semi-s...