نتایج جستجو برای: β2 Glycoprotein I

تعداد نتایج: 1125751  

Journal: :iranian journal of immunology 0
soheila rahgozar division of cell, molecular and developmental biology, department of biology, faculty of science, university of isfahan, isfahan, iran

beta 2 glycoprotein i (β2gpi) is a single chain 50 kda highly glycosylated glycoprotein at an approximate concentration of 4 μm in cells. the abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. in addition, β2gpi has a particular structure in the fifth domain, and is categorized as the major antigen recognized by autoa...

2011
Špela Irman Miha Škarabot Igor Muševič Blaž Rozman Borut Božič

Antibodies against β2-glycoprotein I are a subset of very heterogeneous family of antiphospholipid antibodies. It is well recognised that anti-β2-glycoprotein I antibodies are the main pathogenic players in the autoimmune disease known as antiphospholipid syndrome. Many mechanisms have been proposed through which these autoantibodies could cause microplacental, arterial or venous thrombosis. On...

Journal: :iranian journal of allergy, asthma and immunology 0
regina promberger clinical division of gynecologic endocrinology and reproductive medicine, medical university of vienna, austria katharina walch clinical division of gynecologic endocrinology and reproductive medicine, medical university of vienna, austria rudolf seemann deparetment of craniomaxillofacial and oral surgery, medical university of vienna, austria sophie pils clinical division of gynecologic endocrinology and reproductive medicine, medical university of vienna, austria johannes ott clinical division of gynecologic endocrinology and reproductive medicine, medical university of vienna, austria

etiologic factors for recurrent miscarriage (rm) include autoimmune diseases, the most frequently antiphospholipid syndrome and thyroiditis. some women who suffer from rm might also have an altered immune system. we aimed to evaluate possible associations between anti-thyroid and anti-phospholipid antibodies in women with rm. in a retrospective case series 1 on 156 women with rm, major outcome ...

Soheila Rahgozar

Beta 2 glycoprotein I (β2GPI) is a single chain 50 kDa highly glycosylated glycoprotein at an approximate concentration of 4 μM in cells. The abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. In addition, β2GPI has a particular structure in the fifth domain, and is categorized as the major antigen recognized by autoa...

Journal: :Rheumatology & autoimmunity 2023

Antiphospholipid syndrome (APS) is typically characterized by increased levels of three classes antiphospholipid antibodies, namely lupus anticoagulant, anti-β2-glycoprotein I (anti-β2GPI), and anticardiolipin antibodies. β2-Glycoprotein (β2GPI) a phospholipid-binding protein composed five domains (DI–V) major antigen in APS. β2GPI expressed on the surfaces several cell types, including endothe...

2014
Andrej Artenjak Adrijana Leonardi Igor Križaj Aleš Ambrožič Snezna Sodin-Semrl Borut Božič Saša Čučnik

Patient biological material for isolation of β2-glycoprotein I (β2GPI) and high avidity IgG anti-β2-glycoprotein I antibodies (HAv anti-β2GPI) dictates its full utilization. The aim of our study was to evaluate/improve procedures for isolation of unnicked β2GPI and HAv aβ2GPI to gain unmodified proteins in higher yields/purity. Isolation of β2GPI from plasma was a stepwise procedure combining n...

Journal: :Obstetrics and gynecology 2013
Robert M Silver Corette B Parker Uma M Reddy Robert Goldenberg Donald Coustan Donald J Dudley George R Saade Barbara Stoll Matthew A Koch Deborah Conway Radek Bukowski Carol J Rowland Hogue Halit Pinar Janet Moore Marian Willinger D Ware Branch

OBJECTIVE To compare antiphospholipid antibodies in deliveries with and without stillbirth using a multicenter, population-based case-control study of stillbirths and live births. METHODS Maternal sera were assayed for immunoglobulin (Ig)G and IgM anticardiolipin and anti-β2-glycoprotein-I antibodies. Assays were performed in 582 stillbirth deliveries and 1,547 live birth deliveries. RESULT...

Journal: :Journal of Thrombosis and Haemostasis 2011

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