Objective(s): In this study a series of novel colchicine-like β-acetamidoketones was designed and synthesized as potential tubulin inhibitorsMaterials and Methods: The cytotoxicity of the novel synthesized β-acetamidoketones was assessed against two cancerous cell lines including MCF-7 (human breast cancer cells) and A549 (adenocarcinomi...

microtubules are unique cytoskeletal structures that have structural subunits of αβ tubulin. taxol is a typical microtubule stabilizing drug. the epothilones are other natural products with similar mechanism of action totaxol. despite the highly conserved nature of β-tubulin, some organism like saccharomyces cerevesia is resistance to taxol, but sensitive to epothilones. in order to find differ...

In this report, β-tubulin gene polymorphism was investigated in Haemonchus contortus  populations isolated from sheep flocks in different regions of Khouzestan province, southwestern Iran. The samples were chosen on the basis of regional variation in benzimidazole treatment background of sheep flocks. Our objective was to study the relationship between treatment background andβ -tubulin gene po...

in this report, β-tubulin gene polymorphism was investigated in haemonchus contortus  populations isolated from sheep flocks in different regions of khouzestan province, southwestern iran. the samples were chosen on the basis of regional variation in benzimidazole treatment background of sheep flocks. our objective was to study the relationship between treatment background andβ -tubulin gene po...

during spring and summer of 2010 and 2012, several surveys were conducted in different vineyards in kohgiluyeh & boyer-ahmad (southwestern iran) and kerman (southeastern iran) provinces, with the aim of isolating and identifying fungi associated with grapevine decline diseases. the samples collected comprised diseased grapevines showing yellowing, defoliation, reduced growth, wilting, intervein...

b ackground: due to the lack of a suitable and economic test for the analysis of the polymorphism at codon 167, we developed a new pcr-rflp technique, based on a modified forward primer (ut- hc167 mf-primer), to identify simultaneously the snps at codons 167 and 200 of isotype 1 β-tubu- lin gene of haemonchus contortus . m ethods: there already are several safe and easy methods for identificati...

Aspergillus subgenus Nidulantes accommodates species of industrial and medical importance. Thirty isolates morphologically assigned to subgenus Nidulantes were studied, 25 isolated from cereals in the north and northwestern provinces and the rest from other substrates in Iran. Based on morphological and molecular data (sequences of the ITS rDNA and β-tubulin), nine species were identified belon...