Background: β-eudesmol is a kind of aromatic compound belonging to sesquiterpenoid which exists within not only the bark of magnolia but also Nardostachys jatamansi, Atractylodes lancea, Pterocarpus santalinus, Ginkgo bilobal, Cryptomeria japonica, etc., and there has been progress in medical and pharmaceutic researches on antitumor, anticancer, and anti-inflammatory effects; nervous system sta...

In addition to four previously reported compounds: proximadiol (1), 5α-hydroxy-β-eudesmol (2), 1β-hydroxy-β-eudesmol (4) and 1β-hydroxy-α-eudesmol (5), two new sesquiterpenes, 5α-hydroperoxy-β-eudesmol (3) and 7α,11-dihydroxycadin-10(14)-ene (6) were isolated from the unsaponifiable fraction of the petroleum ether extract of Cymbopogon proximus STAPF. Isolation of compounds 2, 4 and 5 from the ...

Reactive oxygen species are well-known mediators of various biological responses. Recently, new homologues of the catalytic subunit of NADPH oxidase have been discovered in non phagocytic cells. These new homologues (Nox1-Nox5) produce low levels of superoxides compared to the phagocytic homologue Nox2/gp91phox. In this study we examined the effect of β-eudesmol, a sesquiterpenoid alcohol isola...

Purpose: To investigate the role of β-eudesmol in septic liver injury mice.Methods: Mice were intraperitoneally injected with 50 or 100 mg/kg β-eudesmol, and then subjected to cecal ligation puncture for establishment a model 2 h later. Haematoxylin eosin staining was used evaluate histopathological changes tissues. Terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) enzy...

Objective: The study aimed to evaluate the critical physicochemical properties (lipophilicity, aqueous solubility, and degree of ionization) atractylodin β-eudesmol using in vitro testing.
 Methods: Lipophilicity (Log P Log D) was determined shake-flask method (n-octanol/water partition). Aqueous solubility kinetic assay media with pH ranging from 1.2 7.4. ionization (pKa) potentiometric t...

Sandalwood and agarwood essential oils are rare natural comprising fragrant terpenoids that have been used in perfumes incense for millennia. Increasing demand these terpenoids, coupled with difficulties isolating them from sources, led to an interest finding alternative production platforms. Here, we engineered the budding yeast Saccharomyces cerevisiae produce sandalwood agarwood. Specificall...

Beta-eudesmol, a sesquiterpenoid isolated from "So-jutsu" (Atractylodis lanceae rhizomas), is known to have various unique effects on the nervous system. We examined in detail the mechanism by which beta-eudesmol modified neuronal function using rat pheochromocytoma cells (PC-12). Beta-eudesmol at concentrations of 100 and 150 microM significantly induced neurite extension in PC-12 cells, which...

Secondary metabolites are chemical found in plants. These have no role in plant growth but these are important for human because it have many pharmacological activity. Bergenia species such as Bergenia stracheyi, Bergenia ligulata And Bergenia ligulata etc. have many secondary metabolites such as 1. Bergenin 2. Tannic acid 3. Gallic acid 4. Stigmesterol 5. β-Sitosterol 6. catechin 7. (+)-Afzele...

This study investigated the chemical composition, and antimicrobial and anti-wood-decay fungal activities of the essential oil isolated from the leaf of Litsea acuminata (Blume) Kurata from Taiwan. The essential oil from the fresh leaves of L. acuminata was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC–FID and GC–MS. A total of 48 compounds were identif...

Hydrodistilled essential oil of the aerial parts of Laggera crispata (Vahl) Hepper & Wood, collected from the Kumaon region of the western Himalayas was analysed by gas chromatography and gas chromatography–mass spectrometry. Eighty constituents, accounting for 83.9 % of the total oil composition, were identified. The oil was mainly dominated by sesquiterpenoids (45.3 %) and benzenoid compounds...