نتایج جستجو برای: β-carboline

تعداد نتایج: 177796  

Journal: :Chemical & pharmaceutical bulletin 2011
Wei-Hua Jiao Hao Gao Feng Zhao Hou-Wen Lin Yu-Min Pan Guang-Xiong Zhou Xin-Sheng Yao

During further chemical and biological investigations of Picrasma quassioides BENNET, four new bis-β-carboline alkaloids, quassidines E-H (1-4), and three new β-carboline alkaloids, canthin-16-one-14-butyric acid (5), 3-(1,1-dimethoxylmethyl)-β-carboline (6), and 6,12-dimethoxy-3-formyl-β-carboline (7), were isolated from its anti-inflammatory CHCl(3)-soluble fraction. Structures of new compoun...

2018
Jiang-Jiang Qin Wei Wang Xin Li Hemantkumar Deokar John K. Buolamwini Ruiwen Zhang

The β-catenin and MDM2 oncoproteins are overexpressed and constitutively activated in human pancreatic cancer and contribute to its initiation, progression, and metastasis. The Wnt/β-catenin signaling pathway strongly interacts with the MDM2-p53 signaling pathway, accelerating the tumorigenesis and its development. Therefore, therapies inhibiting both β-catenin and MDM2 are suggested to be idea...

ژورنال: Hormozgan Medical Journal 2006
Asghari, GH.R, Ghanadi, A.R, Hemmatian, S,

Introduction: peganum harmala L. (Zygophyllaceae) and varthemia persica DC (Compositeae) were used for co-culture studies. P.harmala was found to be one of the richest natural sources of β-carboline alkaloids. β-carboline alkaloids posses different neuropharmacologic activities including BDZ antagonism, MAOinhibitor and aminoreuptake inhibitor. The production of β-carboline alkaloids in cell ...

2013
P. Bama

Plant and plant products are the major source for the discovery of new drugs. Alangium salviifolium utilized in traditional medicine has resourceful medicinal properties.The aim of present study was to evaluate the biological activity of alkaloid β Carboline harmaline of Alangium salviifolium in cell growth activity inhibition. The potentiality of the alkaloid compound in inhibition of MTHFR wi...

Journal: :Organic & biomolecular chemistry 2015
Ahmed Kamal Yellaiah Tangella Kesari Lakshmi Manasa Manda Sathish Vunnam Srinivasulu Jadala Chetna Abdullah Alarifi

Iodobenzene diacetate was employed as a mild and efficient reagent for one-pot oxidative decarboxylation of tetrahydro-β-carboline acids and dehydrogenation of tetrahydro-β-carbolines to access the corresponding aromatic β-carbolines. To the best of our knowledge this is the first synthesis of β-carbolines via a one-pot oxidative decarboxylation at ambient temperature. The utility of this proto...

Journal: :Molecules 2014
Qinghai Zhang Xikai Shu Feng Jing Xiao Wang Changhu Lin Aiqin Luo

Two high-speed countercurrent chromatography (HSCCC) modes were compared by separation of major alkaloids from crude extract of Picrasma quassioides. The conventional HSCCC separation was performed with a two-phase solvent system composed of petroleum ether-ethyl acetate-methanol-water (5:5:4.5:5.5, v/v/v/v) with 200 mg loading. pH-Zone-refining CCC was performed with two-phase solvent system c...

Journal: :Fitoterapia 2012
Zhen Zhang Yu Zhang Yue-Hu Wang Qiang Zhang Xiao-Hui Yan Ying-Tong Di Hong-Ping He Xiao-Jiang Hao

Three novel β-carboline alkaloids characterized with a unique degraded monoterpenoid moiety, gelebolines A-C (1-3), together with 11 known alkaloids of different types, were isolated from the roots of Gelsemium elegans. The structures of new alkaloids were established on the basis of analysis of spectroscopic data. It is the first example for report of β-carboline from genus Gelsemium (Loganiac...

2014
Suresh Babu Meruva Akula Raghunadh Raghavendra Rao Kamaraju U K Syam Kumar P K Dubey

A novel synthetic methodology has been developed for the synthesis of dihydro-β-carboline derivatives employing oxidative amidation-Bischler-Napieralski reaction conditions using tryptamine and 2,2-dibromo-1-phenylethanone as key starting materials. A number of dihydro-β-carboline derivatives have been synthesized in moderate to good yields using this methodology. Attempts were made towards the...

Journal: :Acta Crystallographica Section C Crystal Structure Communications 2011

Journal: :Molecules 2010
Yong Zeng Yaomou Zhang Qunfang Weng Meiying Hu Guohua Zhong

In a continuing effort to develop novel β-carbolines endowed with better insecticidal activity, a simple high-yielding method for the synthesis of harmine compounds starting from L-tryptophan has been developed and a series of 1,3-substituted β-carboline derivatives have been synthesized and evaluated for their cytotoxicity against insect cultured Sf9 cell line in vitro and insecticidal activit...

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