background and objectives: the genus johrenia belongs to umbelliferae family and contains five species that are endemic to iran. johrenia paucijuga grows widely in the north-west, west and center of iran. so far, there has been no research about phytochemistry of j. paucijuga. in the present study, phytochemicals of the plants have been isolated and their structures have been elucidated. method...

BACKGROUND The present study was in quested to study the effects of β-sitosterol on methyl nitrosourea (MNU) induced mammary gland carcinoma in albino wistar rats. METHODS Animals were randomized and divided into four groups of eight animals each. Group I (sham control 1 % CMC in normal saline p.o.); Group II (toxic control, MNU 47 mg/kg, i.v); Group III (MNU 47 mg/kg, i.v + β-sitosterol, 10 ...

BACKGROUND β-sitosterol is a cholesterol-like phytosterol, which widely distributed in the plant kingdom. Here, anti-fibrotic effect of the β-sitosterol was studied using the activated human hepatic stellate cell (HSC) model and dimethylnitrosamine (DMN)-induced mouse hepatic fibrosis model. METHOD HSCs were activated by transforming growth factor-β (TGF-β) and the collagen-1 and α-smooth mus...

The family Polygonaceae is known for its traditional use in the management of various neurological disorders including Alzheimer's disease (AD). In search of new anti-AD drugs, β-sitosterol isolated from Polygonum hydropiper was subjected to in vitro, in vivo, behavioral and molecular docking studies to confirm its possibility as a potential anti-Alzheimer's agent. The in vitro AChE, BChE inhib...

background and objectives:wild sage(salvia macrosiphon boiss.) known as “marvak” in persian is one of the polymorphic and abundant plants of lamiaceae. the plants whole seeds usually soaked or boiled in hot water are widely used for inflammatory ailments in folk medicine. documents have shown that there is scant information on the chemical constituents of this plant seeds. the current study was...

The metabolic turnover, absolute oral bioavailability, clearance, and volume of distribution for β-sitosterol were measured in healthy subjects. [(14)C]β-Sitosterol was used as an isotopic tracer to distinguish pulse doses from dietary sources and was administered by both oral and intravenous routes. The administered doses of [(14)C]β-sitosterol were in the region of 3 to 4 μg, sufficiently low...

The purified total sterols and β-sitosterol extracted from Sargassum horneri were evaluated for their antidepressant-like activity using the forced swim test (FST) and tail suspension test (TST) in mice. Total sterols and β-sitosterol significantly reduced the immobility time in the FST and TST. Total sterols were administered orally for 7 days at doses of 50, 100, and 200 mg/kg, and β-sitoster...

Introduction: Michelia champaca l. (Magnoliaceae) is an ancient Indian medicinal plant a native of the Indian subcontinent and possessing numerous traditional uses. β-sitosterol is an important plant sterol present in Michelia which is reported to posses’ chemopreventive and adaptogenic properties. In the present study, High Performance thin layer Chromatography has been developed for detection...

The phase behavior of binary mixtures of γ-oryzanol and β-sitosterol and ternary mixtures of γ-oryzanol and β-sitosterol in sunflower oil was studied. Binary mixtures of γ-oryzanol and β-sitosterol show double-eutectic behavior. Complex phase behavior with two intermediate mixed solid phases was derived from differential scanning calorimetry (DSC) and small-angle X-ray scattering (SAXS) data, i...

Christiansen, L.I, 2002. Preparation, analysis and cholesterol lowering effect of a novel microcrystalline β-sitosterol suspension in oil and phase behaviour of β-sitosterol with cholesterol. Dissertationes Biocentri Viikki Universitatis Helsingiensis 11/2002, pp. 54 ISBN 952-10-0508-4 (print) ISBN 952-10-0509-2 (pdf) ISSN 1239-9469 Few efforts have been made to formulate preparations suitable ...