background :   ampc beta lactamases play a significant role in creating resistance to third generation cephalosporins worldwide. they mostly express on chromosome of enterobacteriaceae especially escherichia coli and cause consequential problem in clinical treatment and lead to failure in diagnosis and phenotypic test recommended by clinical and laboratory standards institute.   methods : total...

conclusions a high prevalence of multiple β-lactamase production was observed among the ampc producers (60%), of which the majority co-produced ampc and mbl. the current study results showed correlation between β-lactamase production and the presence of antibiotic resistance genes in the isolates. results all isolates were multidrug resistant. ampc, esbl and mbl production were observed in 35 (...

β-lactamases are enzymes which inactivate the β-lactam antibacterial agents and are one of the major causes of resistance against these drugs. Recently there are reports on the isolation of bacteria which does not produce β-lactamase, but are resistant to penicillins. In the present study, β-laclamase production was determined using iodometric method on 150 ampicillin resistance Escherichia col...

Although β-lactams have been the most effective class of antibacterial agents used in clinical practice for the past half century, their effectiveness on Gram-negative bacteria has been eroded due to the emergence and spread of β-lactamase enzymes that are not affected by currently marketed β-lactam/β-lactamase inhibitor combinations. Avibactam is a novel, covalent, non-β-lactam β-lactamase inh...

The production of β-lactamase enzymes is the main mechanism of resistance to β-lactam antibiotics in gramnegative bacilli. Therefore, it is important to identify the β-lactamases-producing bacteria for the treatment of caused infections. This article aimed to review the recent literature and guidelines regarding phenotypic detection of β-lactamases in common gram-negative bacilli in clinical sa...

the nosocomial infections, caused by multi-drug resistant bacteria, are the most important cause of mortality throughout the world. one important mechanism against beta-lactam antibiotics is the production of beta-lactamases. enterobacteriaceae and non-fermentative bacteria, like pseudomonas aeruginosa and acinetobacter baumannnii may produce these enzymes. currently, there is no vaccine to pre...

Staphylococcus aureus is a common cause of hospital-acquired infections. This bacterium is resistant to β-lactam antibiotics. The aim of this study was to evaluate the prevalence of S. aureus strains producing enzymes capable of destroying β-lactam antibiotics in a hospital environment. This descriptive and analytic study was performed in Besat Hospital, Sanandaj, Iran, 2016, on 158 swabs colle...

β-Lactamases are the main cause of bacterial resistance to penicillins, cephalosporins and related β-lactam compounds. These enzymes inactivate the antibiotics by hydrolysing the amide bond of the β-lactam ring. Class A β-lactamases are the most widespread enzymes and are responsible for numerous failures in the treatment of infectious diseases. The introduction of new β-lactam compounds, which...