Antibiotic resistance among Gram-negative bacilli (GNB) is a rapidly expanding problem due to the organisms’ ability to mutate, and to acquire and transmit plasmids and other mobile genetic elements encoding resistance gene. Beta-lactamase antibiotics are among the most widely prescribed antibiotics worldwide and the emergence of resistance to these agents has resulted in a major clinical crisi...

Amp C beta-lactamases are a type of cephalosporinase enzymes belonging to Class C of Ambler’s structural classification, while assigned to group 3 in the functional classification scheme of Bush (Ambler, 1980; Bush et al., 1995). These enzymes can be either chromosomal or plasmid encoded conferring resistance to both oxyimino (cefotaxime, ceftazidime, ceftriaxone) and 7-α methoxy cephalosporins...

Background and Objective: Antimicrobial resistance has turned into a key medical and public health crisis globally since the injudicious use of magic bullets (drugs). Aim of this study is focused on the clinical isolate and their percentages of resistant to antibiotics in gram positive bacteria such as MRSA, VRSA, and MSSA are common causes of nosocomical, skin structure infections, bacteremia ...

Directed, biologically-driven self-assembly has the potential to yield hybrid multicomponent architectures with applications ranging from sensors and diagnostics to nanoelectronic devices. Critical to these applications is to gain control over the precise orientation and geometry of biomolecules interacting with one-another and with surfaces. Such control has thus far been difficult to achieve ...

Based on starch-iodine agar plate, a novel screening method that can be used to screen for β-lactamase inhibitors from extracts of herbs is established. The extracts of 100 traditional Chinese medicines were screened for βlactamase inhibitors by this method. The inhibition rates of the Rheum palmatum L., Schisandra chinensis (Turcz.) Baill., Hypericum japonicum Thunb., Paederia scandens (Lour.)...